Chronic granulomatous disease

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Unknown (514)
Transcriptomics (256)
Genomics (82)
Proteomics (14)
Metabolomics (9)
Other (5)
Clinical (2)
Methylation profiling (2)

Organisms

Homo sapiens (143)
Mus musculus (49)
Arabidopsis thaliana (11)
Pseudomonas aeruginosa (7)
Saccharomyces cerevisiae (6)
Drosophila melanogaster (6)
Rhizobium leguminosarum (5)
Candida albicans (5)
Rattus norvegicus (4)
Trypanosoma brucei (3)
Escherichia coli (3)
Bos taurus (3)
Bacillus subtilis (2)
Salmonella enterica subsp. enterica serovar Typhimurium (2)
Pseudomonas aeruginosa PAO1 (2)
Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 (1)
Vitis x champinii x Vitis riparia (1)
Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74 (1)
Methanococcus maripaludis S2 (1)
Streptococcus gordonii (1)
Rhodococcus aetherivorans (1)
Synechococcus phage S-PM2 (1)
Salmonella enterica (1)
Brucella abortus (1)
Bacillus subtilis subsp. subtilis str. 168 (1)
Sordaria macrospora (1)
synthetic construct (1)
Streptomyces coelicolor A3(2) (1)
Bacillus anthracis (1)
Aspergillus fumigatus (1)

Organisms

Homo sapiens (19)
Mus musculus (13)
Granulibacter bethesdensis (7)
Aspergillus fumigatus (2)
Francisella philomiragia (2)
Klebsiella pneumoniae subsp. rhinoscleromatis SB3432 (1)
Burkholderia glumae AU6208 (1)
Mycobacterium avium subsp. paratuberculosis K-10 (1)
Burkholderia multivorans CGD2M (1)
Burkholderia multivorans CGD2 (1)
Mycobacterium avium subsp. paratuberculosis (1)
Granulibacter bethesdensis CGDNIH1 (1)
Francisella philomiragia subsp. philomiragia ATCC 25017 (1)
lung metagenome (1)
human metagenome (1)
bovine gut metagenome (1)
Bos taurus (1)
Rattus norvegicus (1)

Repository

biostudies-arrayexpress (237)
ENA (71)
geo (37)
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pride (8)
MassIVE (5)
EGA (3)
GNPS (1)
iProX (1)

Tissue

Neutrophil (2)
Peritoneum (1)
Bronchoalveolar lavage (1)
Bone marrow (1)
Feces (1)
Colon (1)
Cell culture (1)
Macrophage (1)

Disease

Wilms tumour (2)
Normal (2)
Chronic granulomatous disease (2)
Crohn's disease (2)
XCGD (1)
Ulcerative colitis (1)
Active Crohn's disease (1)
Mixoid liposarcoma (1)
Unaffected (1)
Diabetes Mellitus (1)
Inflammatory Bowel Diseases (1)
Leukocyte adhesion deficiency (1)
Severe congenital neutropenia (1)
Pulmonary tuberculosis (1)
Tuberculosis (1)
Colitis (1)
Disease free (1)

Technology Type

Mass Spectrometry (8)
Mass spectrometry (6)
Shotgun proteomics (6)
Mass spectrometry assay (2)
Bottom-up proteomics (2)
Affinity purification coupled with mass spectrometry proteomics (1)
Data-independent acquisition (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (10)
Illumina HiSeq 4000 (7)
ScanArray [PerkinElmer] (4)
Axon- GenePix4000B (4)
NextSeq 500 (4)
GeneChip Scanner 3000 7G (2)
Illumina HiSeq 2000 (2)
Q Exactive (2)
Gas Chromatography MS - positive (2)
Dell R820 (1)
GeneChip Fluidics Station 450 (1)
GeneChip Scanner 3000 (1)
Unspecified (1)
Illumina HiScanSQ (1)
GeneChip hybridization Oven 640 (1)
418 [Affymetrix] (1)
Scanning hardware (1)
NA (1)
N/A (1)
Illumina HiSeq 2500 (1)
Impact II (1)
LTQ Orbitrap (Thermo Fisher Scientific) (1)
Orbitrap Exploris 480 (1)
LTQ Orbitrap Elite (1)
Orbitrap Fusion (1)
Liquid Chromatography MS - negative (1)
Liquid Chromatography MS - positive (1)
Liquid Chromatography MS - negative - HILIC (1)
Liquid Chromatography MS - positive - HILIC (1)
Liquid Chromatography MS - negative - reverse-phase (1)

Publication Date

2010 (30)
2008 (29)
2012 (26)
2014 (24)
2013 (24)
2011 (18)
2016 (15)
2015 (14)
2009 (13)
2007 (13)
2022 (12)
2025 (11)
2018 (9)
2017 (9)
2021 (8)
2026 (7)
2024 (7)
2023 (7)
2020 (7)
2019 (5)
2006 (4)
2004 (3)
2003 (2)

CHEBI ID

CHEBI:16755 (2)
CHEBI:16359 (2)
CHEBI:166451 (1)
CHEBI:168442 (1)
CHEBI:74299 (1)
CHEBI:133001 (1)
CHEBI:43980 (1)
CHEBI:166654 (1)
CHEBI:131388 (1)
CHEBI:137440 (1)
CHEBI:16109 (1)
CHEBI:59226 (1)
CHEBI:165191 (1)
CHEBI:145755 (1)
CHEBI:17902 (1)
CHEBI:88801 (1)
CHEBI:89400 (1)
CHEBI:75278 (1)
CHEBI:165848 (1)
CHEBI:5623 (1)
CHEBI:73959 (1)
CHEBI:3210 (1)
CHEBI:52617 (1)
CHEBI:882 (1)
CHEBI:176462 (1)
CHEBI:89884 (1)
CHEBI:165572 (1)
CHEBI:165558 (1)
CHEBI:49053 (1)
CHEBI:80602 (1)

Metabolite Name

Isovaleric acid (3)
Valeric acid (3)
Propionic acid (3)
Adenine (3)
Indole (2)
Hexanoic acid (2)
Amastatin (2)
Carnosine (2)
Aprobarbital (2)
Acetoin (2)
Heptanoic acid (2)
Gibberellin A79 (2)
2',4',6'-Trihydroxydihydrochalcone (2)
2-oxindole-3-acetate (2)
Octanoic acid (2)
Lys-Arg (2)
Emodin (2)
Biotin (2)
Ala-Gly (2)
Decanoic acid (2)
Ketoleucine (2)
Butyric acid (2)
Methionine (2)
1-Stearoylglycerophosphoserine (2)
Pyochelin (2)
N-Acetylneuraminic acid (2)
Nonanoic acid (2)
Isobutyric acid (2)
Phosphate (2)
N-Acetylvaline (2)

First Public Date

2024 (11)
2022 (10)
2013 (10)
2025 (8)
2017 (8)
2014 (6)
2018 (5)
2026 (4)
2021 (3)
2015 (3)
2023 (1)
2020 (1)
2019 (1)

Classification

bacteria (6)
fungi (2)

Study status

Terminated (1)
Recruiting (1)

Study type

Transcription profiling by array (156)
RNA-seq of coding RNA (21)
RNA-seq of coding RNA from single cells (11)
Comparative genomic hybridization by array (10)
Unknown experiment type (5)
ChIP-chip by tiling array (5)
Methylation profiling by array (5)
ChIP-chip by array (3)
ChIP-seq (3)
Transcription profiling by tiling array (2)
Other (2)
MicroRNA profiling by array (2)
Animal - One-color microarray (1)
MicroRNA profiling by high-throughput sequencing (1)
One-color microarray (1)
Human - Single-cell sequencing (1)
Human - High-throughput sequencing (1)
Human - One-color microarray (1)
ScATAC-seq (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of non coding RNA (1)
Interventional (1)
Observational (1)

Release Date

2022 (55)
2019 (52)
2021 (47)
2016 (47)
2020 (46)
2010 (46)
2023 (43)
2014 (40)
2013 (39)
2025 (39)
2008 (37)
2012 (36)
2024 (35)
2017 (34)
2011 (32)
2018 (31)
2015 (28)
2009 (22)
2007 (20)
2006 (8)
2004 (5)
2026 (3)
2003 (3)
2005 (1)
2002 (1)
2000 (1)

Lab affiliation

Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK (1)
Conway Institute, School of Medicine, University College Dublin, Ireland (1)
Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom (1)
Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency (Lopukhin FRCC PCM), Head of the Proteomic Analysis Laboratory (1)
Lab of Proteome Research, Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia (1)
Cambridge Institute of Therapeutic Immunology and Infectious Disease, Univeristy of Cambridge, UK (1)
The Institute of Cancer Research, London (1)
Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom (1)

Location

Belgium (1)
United States (1)

Keyword

Remicade (1)
CGD Infection (1)
Chorionic Granulomatous Disease (1)
CGD (1)
IBD (1)
Infliximab (1)
Inflammatory Bowel Disease (1)

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Transcription profiling of peripheral blood monocytes from healthy humans and from those with Chronic Granulamatous Disease in response to stimulation with peptidoglycan and lipopolysaccharide

Persons with Chronic Granulomatous Disease, are susceptible to a narrow range of infections resulting from the failure of cells to generate toxic reactive oxygen species (ROS) required for phagocytice oxidative killing of microorganisms. For unknown reasons, many inflammatory conditions (inflammato...

ORGANISM(S): Homo sapiens

2008-11-05 | E-FPMI-9 | biostudies-arrayexpress

Transcription profiling of human polymorphonuclear leukocytes (PMNs) from healthy individuals vs patients with X-linked chronic granulomatous disease

Polymorphonuclear leukocytes (PMNs) were obtained from healthy individuals (Healthy1, Healthy2, Healthy3, and Healthy4) or patients with X-linked chronic granulomatous disease (XCGD1, XCGD2, XCGD3, XCGD4, XCGD5, and XCGD6). The studies were performed in accordance with a protocol approved by the Ins...

ORGANISM(S): Homo sapiens

2007-09-29 | E-GEOD-935 | biostudies-arrayexpress

Simultaneous Host-Pathogen transcriptome analysis during Granulibacter bethesdensis infection of normal and chronic granulomatous disease neutrophils

Polymorphonuclear leukocytes (PMN) from patients with chronic granulomatous disease (CGD) fail to produce microbicidal concentrations of reactive oxygen species due to mutations in NOX2. Patients with CGD suffer from severe, life-threatening infections and inflammatory complications. Granulibacter...

ORGANISM(S): Homo sapiens

2015-09-08 | E-GEOD-55849 | biostudies-arrayexpress

Affymetrix SNP array data for Genomic Instability and Myelodysplasia with Monosomy 7

Gene modified autologous hematopoietic stem cells (HSC) can provide significant clinical benefits to patients suffering from X-linked chronic granulomatous disease (X-CGD), a rare inherited immunodeficiency characterized by recurrent, often life threatening bacterial and fungal infections. Here we...

ORGANISM(S): Homo sapiens

2010-01-12 | E-GEOD-19523 | biostudies-arrayexpress

Genome wide gene expression analysis of chronic granulomatous disease patients

Whole blood was collected from chronic granulomatous patients, carriers and healthy controls. RNA was isolated from whole blood and globin removal was performed for all samples. The cells were not selecter or stimulated ex vivo.

ORGANISM(S): Homo sapiens

2014-11-01 | E-GEOD-44969 | biostudies-arrayexpress

Gut Microbiota and Bile Acids Profiles study of Ulcerative Colitis and Crohn's Disease Patients

The global incidence of inflammatory bowel disease (IBD) is increasing, with dysbiosis of the gut microbiota identified as a significant factor contributing to chronic intestinal inflammation. This study aims to elucidate the gut microbiota and serum bile acid profiles in patients with ulcerative...

2026-03-19 | MTBLS14084 | MetaboLights

Infliximab to Treat Crohn’S-like Inflammatory Bowel Disease in Chronic Granulomatous Disease

This study will determine if the drug infliximab is safe for treating inflammatory bowel disease (IBD) in patients with chronic granulomatous disease (CGD). IBD is an inflammation or irritation of the gut that leads to symptoms such as diarrhea, bloating and stomach cramps. CGD is an inherited disea...

2028867 | ecrin-mdr-crc

Interferon-gamma 1b-Induced Gene Expression Alters Neutrophil Function in Patients with Chronic Granulomatous Disease

IFNG decreases incidence of infections in chronic granulomatous disease (CGD) without affecting inability of CGD neutrophils to generate essential microbicidal oxidants. Neutrophil (PMN) function, gene expression, and biochemical parameters were measured off IFN-γ and 10-12 hours after 1st and 4th d...

ORGANISM(S): Homo sapiens

2024-07-01 | E-MTAB-13674 | biostudies-arrayexpress

Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.

BACKGROUND & AIMS: The cause of Crohn's disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation. Case-control studies of patients...

2023-11-16 | MTBLS300 | MetaboLights

Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease

PRJNA909313 | ENA

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887 Results

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BACKGROUND & AIMS: The cause of Crohn's disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation. Case-control studies of patients...

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