Chronic kidney disease (ckd)

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Unknown (9182)
Genomics (425)
Transcriptomics (306)
Proteomics (107)
Metabolomics (28)
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Genomic (5)
Clinical (2)
Methylation profiling (2)

Organisms

Mus musculus (201)
Homo sapiens (137)
Schizophyllum commune H4-8 (61)
Mycobacterium tuberculosis SP7 (61)
Oryza sativa Japonica Group (61)
Candidatus Endoriftia persephonae (61)
Mycobacterium tuberculosis SP10 (61)
Mycobacterium tuberculosis SP13 (61)
Mycobacterium tuberculosis SP22 (61)
Chlamydomonas reinhardtii (61)
Pyricularia oryzae P131 (61)
Enterococcus mundtii CRL35 (61)
Oncorhynchus tshawytscha (61)
Pseudomonas canadensis (61)
Strongylocentrotus purpuratus (61)
Influenza A virus (A/California/04/2009(H1N1)) (61)
Homo (61)
Pseudomonas aeruginosa PAO1H2O (61)
Human alphaherpesvirus 1 strain 17 (61)
Rattus norvegicus (35)
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synthetic construct (3)
Felis catus (2)
cellular organisms (2)
Nicotiana benthamiana (1)
Canis lupus familiaris (1)
Sus scrofa domesticus (1)
Rattus (1)
Mus sp. (1)
Mus (1)

Organisms

Mus musculus (149)
Homo sapiens (97)
Rattus norvegicus (21)
mouse gut metagenome (7)
Sus scrofa (3)
human gut metagenome (3)
Felis catus (2)
rat gut metagenome (2)
Canis lupus familiaris (2)
human feces metagenome (1)
Sus scrofa domesticus (1)
Rattus (1)
human oral metagenome (1)

Repository

ENA (392)
geo (257)
biostudies-arrayexpress (87)
pride (61)
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jPOST (8)
EGA (6)
dbGaP (5)
EVA (1)
PanoramaPublic (1)

Tissue

Kidney (19)
Urine (12)
Blood plasma (5)
Epithelial cell (4)
Muscle (3)
Blood serum (3)
Heart (2)
Kidney (2)
Liver (2)
Parathyroid gland (2)
Extracellular vesicle (2)
Heart (2)
Liver (2)
Blood cell (2)
Blood (2)
Proximal tubular epithelium (1)
Glomerular endothelial cell (1)
Endocrine gland (1)
Renal medulla (1)
Renal cortex (1)
Vascular smooth muscle cell (1)
Kidney field (1)
Blood vessel (1)
Arteriole (1)
Vascular associated smooth muscle cell (1)
HUVEC cell (1)
Cecum (1)
Endothelial cell (1)
Aorta (1)
Peritoneum (1)

Disease

Chronic kidney disease (27)
Chronic kidney disease (10)
Disease free (2)
Cancer- gastric (1)
Diabetes mellitus (1)
Kidney disease (1)
Congestive heart failure (1)
Autosomal dominant disease (1)
Polycystic kidney disease (1)
Cystinuria (1)
Alport syndrome (1)
Uremia (1)
Pancreatitis (1)
Polycystic Kidney (1)
Kidney disease (1)
Multiple myeloma (1)
Renal failure (1)
Atherosclerosis (1)
Type 2 diabetes mellitus (1)

Technology Type

Mass Spectrometry (62)
Shotgun proteomics (33)
Bottom-up proteomics (19)
Mass spectrometry (14)
Data-dependent acquisition (10)
Data-independent acquisition (9)
NMR (8)
NMR spectroscopy (3)
Top-down proteomics (3)
Mass spectrometry assay (2)
ESI (1)
Mass spectrometry imaging (1)
SWATH MS (1)
SRM/MRM (1)
Gel-based experiment (1)

Instrument Platform

Liquid Chromatography MS - negative - reverse phase (7)
Liquid Chromatography MS - positive - reverse phase (7)
Illumina NovaSeq 6000 (3)
Q Exactive (3)
Illumina HiSeq 2000 (2)
Illumina HiSeq 4000 (2)
Q Exactive Plus (2)
Orbitrap Exploris 480 (2)
Q Exactive HF-X (2)
Liquid Chromatography MS - alternating - reverse phase (2)
Liquid Chromatography MS - negative - HILIC (2)
Liquid Chromatography MS - positive - HILIC (2)
Illumina HiSeq 2000 platform (1)
Ion Torrent Proton (1)
DNBSEQ-G400 (1)
Illumina HiSeq 2500 (1)
TimsTOF fleX (1)
Orbitrap Eclipse (1)
Orbitrap Fusion (1)
QTRAP 6500+ (1)
LTQ Orbitrap (1)
Liquid Chromatography MS - alternating - HILIC (1)
Nuclear Magnetic Resonance (NMR) (1)
Liquid Chromatography MS - Negative (LC-MS (Negative)) (1)
Liquid Chromatography MS - Positive (LC-MS (Positive)) (1)
Gas Chromatography MS - Positive (GC-MS (Positive)) (1)
Bruker (1)
Nuclear Magnetic Resonance (NMR) - (1)
Liquid Chromatography MS - positive - reverse-phase (1)
Liquid Chromatography MS - negative - reverse-phase (1)

Publication Date

2025 (89)
2026 (80)
2024 (59)
2023 (41)
2022 (28)
2021 (25)
2013 (24)
2015 (20)
2019 (16)
2020 (15)
2016 (15)
2010 (10)
2018 (9)
2012 (8)
2017 (6)
2009 (6)
2014 (3)
2011 (1)

CHEBI ID

CHEBI:16737 (9)
CHEBI:17724 (7)
CHEBI:16335 (7)
CHEBI:16704 (7)
CHEBI:18257 (7)
CHEBI:16919 (7)
CHEBI:17368 (7)
CHEBI:18053 (6)
CHEBI:17752 (6)
CHEBI:35581 (6)
CHEBI:17015 (6)
CHEBI:7916 (6)
CHEBI:17154 (6)
CHEBI:16708 (6)
CHEBI:17568 (6)
CHEBI:16750 (6)
CHEBI:18211 (6)
CHEBI:37024 (6)
CHEBI:18344 (6)
CHEBI:27480 (5)
CHEBI:17405 (5)
CHEBI:48430 (5)
CHEBI:16755 (5)
CHEBI:16235 (5)
CHEBI:17750 (5)
CHEBI:35697 (5)
CHEBI:16040 (5)
CHEBI:17562 (5)
CHEBI:16797 (5)
CHEBI:15753 (5)

Metabolite Name

Indole (7)
1-Aminocyclopropanecarboxylic acid (5)
N6-Acetyl-L-lysine (5)
Thiamine (5)
Argininosuccinic acid (5)
Betaine (5)
Cytosine (5)
Uracil (5)
Thymine (5)
L-Proline (5)
L-Threonine (5)
Creatinine (5)
L-Methionine (5)
Oleic acid (5)
Creatine (5)
L-Phenylalanine (5)
Guanosine (5)
Uridine (5)
Dimethylglycine (4)
CMP (4)
AMP (4)
Niacinamide (4)
1-Methylnicotinamide (4)
Sphinganine (4)
Sphingosine (4)
Pyroglutamic acid (4)
4-Pyridoxic acid (4)
Ornithine (4)
L-Lysine (4)
L-Arginine (4)

First Public Date

2025 (93)
2026 (77)
2024 (66)
2023 (49)
2022 (28)
2021 (19)
2020 (15)
2019 (13)
2014 (10)
2017 (9)
2015 (5)
2018 (4)
2016 (3)
2013 (1)

Study status

Not yet recruiting (1)
Completed (1)

Study type

Transcription profiling by array (66)
RNA-seq of coding RNA (7)
Methylation profiling by array (3)
Comparative genomic hybridization by array (2)
Proteomic profiling by array (2)
RNA-seq of non coding RNA (2)
Plant - High-throughput sequencing (1)
Animal - High-throughput sequencing (1)
Transcription profiling by RT-PCR (1)
MicroRNA profiling by array (1)
Methylation profiling by high throughput sequencing (1)
Observational (1)
Interventional (1)

Release Date

2025 (1356)
2022 (1291)
2023 (1154)
2024 (1101)
2021 (1053)
2020 (741)
2019 (610)
2018 (474)
2017 (368)
2016 (265)
2026 (207)
2015 (197)
2014 (145)
2013 (106)
2012 (67)
2010 (46)
2011 (44)
2009 (32)
2008 (10)
2007 (1)
2006 (1)

Lab affiliation

Proteomics core facility, Biomedical Research Institute, Seoul National University Hospital (3)
Nestlé Research – Nestlé Institute of Food Safety & Analytical Sciences (2)
Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München (2)
University of Algarve, Centre of Marine Sciences (CCMAR), Campus de Gambelas, 8005-139 Faro, Portugal (1)
Labo Pathophysiology, Department of Biomedical Sciences, University of Antwerp. Belgium (1)
UCB Biopharma (where the work was done) MSD UK (current) (1)
Department of Nephrology, Daping hospital, Army Medical Center, Army Medical University, Chongqing, China (1)
Center of Systems Biology, Biomedical Research Foundation, Academy of Athens, Greece (1)
University of Chicago Pritzker School of Medicine, Section of Nephrology, Chicago, IL 60637 USA (1)
BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic (1)
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA (1)
Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel. (1)
Hadassah - Hebrew University Medical Center, Department of Nephrology (1)
Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Cardiovascular and Metabolic Disease, 31432 Toulouse, France Université Toulouse III Paul-Sabatier, 31062 Toulouse, France. (1)
Department of Nephrology and Rheumatology, Shanghai Tenth People's Hospital of Tongji University School of Medicine, Shanghai, People's Republic of China (1)
Associate Professor Department of Physiology Medical College of Wisconsin (1)
Conway Institute Research Fellow Special Lecturer in Clinical Pharmacology School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland. (1)
Department of Anatomy and Developmental BiologyMonash University, Clayton, Victoria, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. Alexander N Combes alex.combes@monash.edu. David J Nikolic-Paterson david.nikolic-paterson@monash.edu. (1)
Proteomics Center Erasmus University Medical Center (1)
IRCCS Ist. Gaslini (1)
Hadassah - Hebrew University Medical Center, Department of Nephrology and Hypertension (1)
University of Copenhagen, Copenhagen Center for Glycomics (1)
State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China (1)
Proteomics Unit (1)
Departamento de Biología de Sistemas, Universidad de Alcalá, 28871 Alcala de Henares, Madrid, Spain (1)
Clinical Medical Research Center, The Second Clinical Medical College of Jinan University (Shenzhen People’s Hospital), Shenzhen, Guangdong;Department of Nephrology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong (1)
Department of Applied Chemistry, Institute of Natural Science, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin, Republic of Korea; Department of Biomedical Science and Technology, Kyung Hee Medical Science Research Institute, Kyung Hee University, Seoul, Republic of Korea. (1)
Department of Medical BioSciences, Radboud Institute for Molecular Life Sciences, Radboud university medical centre, 6500 HB, Nijmegen, The Netherlands. (1)
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA (1)
University Hospital of Zurich (USZ) (1)

Location

India (1)
Australia (1)

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A Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease

Identification of chronic kidney disease patients at risk of progressing to end-stage renal disease (ESRD) is essential for treatment decision-making and clinical trial design. Here, we explored whether proton nuclear magnetic resonance (NMR) spectroscopy of blood plasma improves the currently best ...

2019-07-26 | MTBLS798 | MetaboLights

Tissue, urine and serum NMR metabolomics dataset from a 5/6 nephrectomy rat model of chronic kidney disease

Serum, urine and tissue from a rat model of chronic kidney disease (CKD) were analysed using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics methods, and compared with samples from sham operated rats. Both urine and serum were sampled at multiple timepoints, and the results have ...

2020-11-16 | MTBLS2052 | MetaboLights

Dysregulation of the 3β-Hydroxysteroid Dehydrogenase Type 2 Enzyme and Steroid Hormone Biosynthesis in Chronic Kidney Disease

Chronic kidney disease (CKD) presents a critical global health challenge, marked by the progressive decline of renal function. This study explores the role of the 3β-hydroxysteroid dehydrogenase type 2 enzyme (HSD3B2) and steroid hormone biosynthesis pathway in CKD pathogenesis and progression. U...

2024-10-10 | MTBLS10715 | MetaboLights

DNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights

Oral dysbiosis initiates periodontal disease in experimental kidney disease

BACKGROUND AND HYPOTHESIS: It is presently unclear why there is a high prevalence of periodontal disease in individuals living with chronic kidney disease. Whilst some have argued that periodontal disease causes chronic kidney disease, we hypothesized that alterations in saliva ...

2025-09-04 | MTBLS1833 | MetaboLights

Anti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 10)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3056 | MetaboLights

Anti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

2021-07-22 | MTBLS3003 | MetaboLights

Development of gene expression profiles in human chronic kidney disease

A microarray analysis with renal biopsy specimens from CKD patients was conducted in order to identify the responsible genes associated with tubulointerstitial fibrosis and tubular cell injury in CKD. This study showed microarray profiles in total 53 biopsy specimens of CKD patients. In the discover...

ORGANISM(S): Homo sapiens

2015-08-16 | E-GEOD-66494 | biostudies-arrayexpress

Tissue Transcriptome Driven Identification of Epidermal Growth Factor as a Chronic Kidney Disease Biomarker

We identified EGF as the top candidates predicting kidney function through an intrarenal transcriptome-driven approach, and demonstrated it is an independent risk predictor of CKD progression and can significantly improve prediction of renal outcome by established clinical parameters in diverse popu...

ORGANISM(S): Homo sapiens

2015-12-14 | E-GEOD-69438 | biostudies-arrayexpress

Transcription profiling of human patients with chronic kidney disease

Several reports have focused on the identification of biological elements involved in the development of abnormal systemic biochemical alterations in chronic kidney disease, but this abundant literature results most of the time fragmented. To better define the cellular machinery associated to this c...

ORGANISM(S): Homo sapiens

2009-12-04 | E-GEOD-15072 | biostudies-arrayexpress

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BACKGROUND AND HYPOTHESIS: It is presently unclear why there is a high prevalence of periodontal disease in individuals living with chronic kidney disease. Whilst some have argued that periodontal disease causes chronic kidney disease, we hypothesized that alterations in saliva ...

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