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TranscriptomicsTranscription profiling of human leukocytes from chronic myeloid leukemia patients exhibiting differing responses to imatinib
This is a class prediction experiment, where the class is the response status to imatinib (also called Gleevec), a drug used to treat patients with chronic myelogenous leukemia (CML). There are two data sets, a training set (from Leipzig, 8 Responders and 5 Non-Responders) and a validation set (fro...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2535 | biostudies-arrayexpress
TranscriptomicsRECURRENT SETBP1 MUTATIONS IN ATYPICAL CHRONIC MYELOID LEUKEMIA
RNA-Seq analysis of atypical chronic myeloid leukemia samples We sequenced leukemic mRNA from 13 Atypical Cronic Mieloid Leukemia (aCML) samples by Illumina GAIIx. Transcriptomic profiles, differentially expressed genes and pathway enrichment analysis were obtained comparing 7 SETBP1-mutated sample...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42146 | biostudies-arrayexpress
TranscriptomicsMusashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to r...
ORGANISM(S): Homo sapiens 
2010-07-11 | E-GEOD-16432 | biostudies-arrayexpress
ProteomicsThe HLA ligandome landscape of chronic myeloid leukemia delineates novel T-cell epitopes for immunotherapy
Anti-leukemia immunity plays an important role for disease control and maintenance of tyrosine kinase inhibitor (TKI)-free remission in chronic myeloid leukemia (CML). Antigen-specific immunotherapy holds promise to strengthen immune control in CML, but requires the identification of CML-associated ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-11 | PXD010450 | Pride
Mass spectrometry Chronic myeloid leukemia Immunopeptidome 
TranscriptomicsGene expression changes associated with progression and response in chronic myeloid leukemia
Chronic myeloid leukemia (CML) is a hematopoetic stem cell disease with distinct biological and clinical features. The biological foundation of the stereotypical progression from chronic phase through accelerated phase to blast crisis is poorly understood. We used DNA microarrays to compare gene exp...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-4170 | biostudies-arrayexpress
TranscriptomicsCharacterization of miRNomes in acute and chronic myeloid leukemia cells
An in-depth analysis of miRNomes in 3 human myeloid leukemia cell lines was carried out to comprehensively identify miRNAs that distinguish acute and chronic myeloid leukemias and relate to myeloid cell differentiation. Characterization the miRNomes in 3 myeloid leukemia cell lines.
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-48059 | biostudies-arrayexpress
TranscriptomicsIdentification of copy number alterations by array comparative genomic hybridization in patients with late chronic or accelerated phase chronic myeloid leukemia treated with imatinib mesylate
The outcome of treating chronic myeloid leukemia (CML) with imatinib mesylate (IM) is inferior when therapy is commenced in late chronic or accelerated phase as compared to early chronic phase. This may be attributed to additional genomic alterations that accumulate during disease progression. We so...
ORGANISM(S): Homo sapiens 
2011-03-15 | E-GEOD-23946 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of chronic myelogenous leukemia (CML) and normal, quiescent and dividing haematopoietic cells
Quiescent and dividing hemopoietic stem cells (HSC) display marked differences in their ability to move between the peripheral circulation and the bone marrow. Specifically, long-term engraftment potential predominantly resides in the quiescent HSC subfraction, and G-CSF mobilization results in the ...
ORGANISM(S): Homo sapiens 
2014-04-25 | E-MTAB-2508 | biostudies-arrayexpress
TranscriptomicsNoncoding RNA expression profile of dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib
Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some patients also develop resistance or intolerance to dasatinib. To identify potential molecular pathways involved in primary resistance to dasa...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-33288 | biostudies-arrayexpress
TranscriptomicsDynamic transcriptomes of human myeloid leukemia cells
To identify the mechanisms controlling chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) in humans, we analyzed genome-wide transcription dynamics in three myeloid leukemia cell lines (K562, HL-60, and THP1) using high-throughput sequencing technology. Using KEGG analysis, we found tha...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-46164 | biostudies-arrayexpress
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