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MetabolomicsDisturbed Microbiota-Metabolites-Immune Interaction Network is Associated with Olfactory Dysfunction in Patients with Chronic Rhinosinusitis

PURPOSE: Olfactory dysfunction (OD) is a debilitating symptom frequently reported by patients with chronic rhinosinusitis (CRS) and it is associated with a dysregulated sinonasal inflammation. However, little information is available about the effect of the inflammation-related n...

2023-05-12 | MTBLS7584 | MetaboLights
MetabolomicsResearch on the microbiota and metabolic characteristics of type 2 chronic rhinosinusitis based on the analysis of 16S amplicon sequencing combined with metabolomics

Objective:

To investigate the diversity of nasal microbiota and metabolic characteristics of patients with Type 

2 chronic rhinosinusitis, as well as the interactions and potential regulatory relationships between 

the nasal microbiota and their metabolites by conducti...

2025-10-21 | MTBLS13192 | MetaboLights
TranscriptomicsRNA-seq of Staphylococcus aureus isolates from chronic rhinosinusitis patients (CSS) against healthy individuals
S. aureus isolates from chronic rhinosinusitis patients and healthy individuals were cultured overnight. The strains belonged to clonal complexes CC7 (CSS66 and MIN142) and CC15 (CSS126 and MIN93) that are both prevalent in Germany. These isolates have previously been characterized in Tuchscherr, L....
ORGANISM(S): Staphylococcus aureus 
2026-02-12 | E-MTAB-16578 | biostudies-arrayexpress
ProteomicsIn-depth proteomic analysis of nasal secretions from chronic rhinosinusitis and nasal polyps
Considering the complex and multifarious features of Chronic rhinosinusitis (CRS) including immunologic patterns, novel modalities are needed to reflect clinical and pathophysiological endotypes beyond nasal polyps.We aimed to investigate the proteome of nasal secretions on filter paper from CRS pat...
ORGANISM(S): Homo sapiens (Human) 
2019-07-29 | PXD013330 | Pride
Nasal secretion Chronic rhinosinusitis Nasal polyps Label-free quantification 
TranscriptomicsMicroRNA expression in chronic rhinosinusitis
Increasing evidence suggests that CRS is a heterogeneous group of sinus disorders involving overlapping but distinct disease entities.The factors leading to different CRS phenotypes remain enigmatic. The role of miRNAs in the regulation of immunological and inflammatory processes is beginning to eme...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-32300 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local inflammation of the upper airways which persists for at least 12 weeks. CRS is one of the most common chronic diseases in adults in the United States, affecting over 30 million Americans. CRS is frequently divided into 2 ...
ORGANISM(S): Homo sapiens 
2012-03-27 | E-GEOD-36830 | biostudies-arrayexpress
TranscriptomicsExon Array Analysis of Asthmatic Chronic Rhinosinusitis with Nasal Polyps
Asthmatic chronic rhinosinusitis with nasal polyps (aCRSwNP) is a common disruptive eosinophilic disease. Therefore, we sought to identify gene expression changes in nasosinus inflamed mucosa and adjacent polyp tissue from subjects with aCRSwNP. Twelve asthmatic chronic rhinosinusitis (aCRS) subjec...
ORGANISM(S): Homo sapiens 
2010-08-12 | E-GEOD-23552 | biostudies-arrayexpress
GenomicsTranscriptomic profiling of chronic rhinosinusitis with nasal polyps
Transcriptomic profiling of chronic rhinosinusitis with nasal polyps
PRJNA1494473 | ENA
TranscriptomicsMicroarray analysis of epithelial and fibroblast cells in chronic rhinosinusitis
Chronic rhinosinusitis without polyps (CRSsNP) is typified by inflammation of the sinonasal epithelium and the development of fibrosis. The precise pathophysiology of this common condition remains elusive. Here we aim to investigate the transcriptome (RNA transcripts in the cell) of the component ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-69093 | biostudies-arrayexpress
TranscriptomicsA global analysis of tandem 3'UTRs in eosinophilic chronic rhinosinusitis with nasal polyps
Background: Alternative polyadenylation (APA) is emerging as a widespread mechanism of gene regulation. The usage of APA sites allows a single gene to encode multiple mRNA transcripts with different 3'-untranslated region (3'UTR) lengths. Many disease processes reflect the importance of the regulati...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-39957 | biostudies-arrayexpress
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