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ProteomicsRNA sequencing and proteomic profiling reveal alterations by MPTP in chronic stomach mucosal injury in tree shrew Chinese (Tupaia belangeri chinensis)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that can cause gastrointestinal ulcers by affecting dopamine levels. Therefore, MPTP has been considered a toxic substance that causes gastric ulcer disease in experimental animals. In this study, tree shrews were used as the animal...
ORGANISM(S): Tupaia belangeri 
2024-01-26 | PXD047458 | Pride
Rna sequencing Mptp Chronic stomach mucosal injury Proteomic profiling Tree shrew 
UnknownRNA sequencing and proteomic profiling reveal alterations by MPTP in chronic stomach mucosal injury in tree shrew Chinese (Tupaia belangeri chinensis).
Not available
S-EPMC10761816 | biostudies-literature
MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
UnknownTHBS4/integrin α2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection.
Not available
S-EPMC8386559 | biostudies-literature
TranscriptomicsMKN74 gastric epithelial cells infected with Enterococcus faecalis for 24hrs or 5day
MKN74 cells were infected for 24 h or 5 days. For the 24 h infection, 80% confluent MKN74 cells were washed three times in PBS and incubated in antibiotic free medium. Overnight-grown colonies of E. faecalis were collected and added to the MKN74 cell culture at a multiplicity of infection (MOI) of 5...
ORGANISM(S): Homo sapiens 
2012-04-02 | E-MEXP-3496 | biostudies-arrayexpress
TranscriptomicsHuman colon expression in healthy controls and UC
Activation of inflammatory pathways in human IBD. Leukocyte recruitment pathways including those for eosiniphils are activated in the affected colon in IBD. However, the functional implications of this are not known. We hypothesized that pro-inflammatory eotaxin (CCL11) dependent networks would be...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-10191 | biostudies-arrayexpress
MetabolomicsOrnithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection

Colonization by H. pylori is associated with a wide range of gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response and the pathogen affect the outcome of disease. One major component ...

2022-06-15 | MTBLS3235 | MetaboLights
TranscriptomicsTranscription profiling by array of human patients with acute myeloid leukemia and chemotherapy-induced oral mucositis
Chemotherapy may cause DNA damage within the oral mucosa of cancer patients leading to mucositis, a dose-limiting side effect for effective cancer treatment. We used whole genome gene expression analysis to identify cellular damage to the mucosal tissue occuring two days post induction chemotherapy ...
ORGANISM(S): Homo sapiens 
2009-01-14 | E-GEOD-10746 | biostudies-arrayexpress
UnknownScutellariae Radix and Citri Reticulatae Pericarpium Mixture Regulate PPARγ/RXR Signaling in Reflux Esophagitis.
Not available
S-EPMC8752236 | biostudies-literature
TranscriptomicsTranscription profiling of human samples from intervention study with two doses of iron (as ferrous gluconate via intestinal perfusion) to study the effect on genome wide gene expression in the small intestine
Human intervention study with two doses of iron (as ferrous gluconate via intestinal perfusion) to study the effect on genome-wide gene expression in the small intestine, in order to obtain detailed information about intestinal transcriptomics in vivo.
ORGANISM(S): Homo sapiens 
2006-05-01 | E-MEXP-325 | biostudies-arrayexpress
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