Mptp - OmicsDI

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CHEBI ID

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CHEBI:6560 (1)

Metabolite Name

(-)-Strychnine (1)
(+/-)-Ornidazole (1)
(+-)-albendazolesulfoxide (1)
4-hydroxy-3-methoxyamphetamine (1)
(+/-)-Coniine (1)
(10E,12E,14E)-16-Hydroxy-9-oxo-10,12,14-octadecatrienoic acid (1)
(1E)-1-{[1-(Propyldisulfanyl)propyl]sulfanyl}-1-propene (1)
(2,4-Dihydroxyphenyl)(hydroxy)acetic acid (1)
(2E)-2-[(4Z)-5-(Methylsulfinyl)-4-penten-2-yn-1-ylidene]-1,6-dioxaspiro[4.4]non-3-ene (1)
(2E,8Z)-10-Hydroxy-2,8-decadiene-4,6-diynoic acid (1)
(2R)-3-{[(2-Aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl(11Z,14Z,17Z)-11,14,17-icosatrienoate (1)
(2R)-3-{[(2-Aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl(9Z)-9-hexadecenoate (1)
(2S,4aR,4bR,6aS,12bS,12cS,14aS)-2-(2-Hydroxy-2-propanyl)-12b,12c-dimethyl-3,4,5,6,6a,7,12,12b,12c,13,14,14a-dodecahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indole-4a(4bH)-carbaldehyde (1)
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(3beta,24R,24'R)-fucosterolepoxide (1)
(3S)-3-{[(3S)-3-Aminobutanoyl]amino}-5-methylhexanoic acid (1)
(4beta,12R)-12,13-Epoxytrichothec-9-en-4-ylacetate (1)
(5E)-4-Hydroxy-6-{5-hydroxy-3-oxo-2-[(2Z,5Z,8Z)-2,5,8-undecatrien-1-yl]cyclopentyl}-5-hexenoic acid (1)
(5R,6S)-3-({(3S)-1-[(1E)-Ethanimidoyl]-3-pyrrolidinyl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (1)
(6alpha,11beta)-6,9-Difluoro-11,21-dihydroxy-3,20-dioxopregna-1,4-dien-17-ylbutyrate (1)
(7Z,9Z,12Z,15Z,18Z,21Z)-7,9,12,15,18,21-Tetracosahexaenoic acid (1)
(8E)-10-Hydroxy-8-decenoic acid (1)
(S)-3,5-DHPG (1)
.alpha.-Aminoadipic acid (1)
[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl](hydroxy)acetic acid (1)
{N'-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-N-methylcarbamimidamido}acetic acid (1)
1-(1H-Imidazo[4,5-c]pyridin-4-yl)ethanone (1)
1-[2-(3-Hydroxy-1-propen-2-yl)-2,3-dihydro-1-benzofuran-5-yl]ethanone (1)
10-Oxo-8-azatricyclo[5.3.1.0~3,8~]undec-5-yl1H-indole-3-carboxylate (1)

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Modelling Approach

Ordinary differential equation model (1)

Study type

Transcription profiling by array (25)
RNA-seq of coding RNA (4)
Transcription profiling by SAGE (2)
Unknown experiment type (2)
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Release Date

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Lab affiliation

Institut Pasteur 25 Rue du Docteur Roux Paris 75015 (2)
Army medical university (1)
Associate Professor, Neuroscience, The Scripps Research Institute Florida (1)
College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, P.R. (1)
Insitute of Basic Medical Sciences, Chinese Academy of Medical Sciences (1)
Instituto de Biomedicina de Sevilla (IBiS)-CSIC (1)
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering of Life Science, Nantong University, Nantong, China. (1)
MRC - London Institute of Medical Sciences (1)
Medical Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences/Peking Union Medical College, Kunming , China (1)
Mitochondrial biology group, Institut Pasteur, Paris (1)
Neurodegenerative Diseases Research Group, Korea Brain Research Institute (1)
School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, United Kingdom (1)
Yale University (1)

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Expression data from naM-CM-/ve and MPTP-exposed cholinergic transgenic mice

PD is the second most common neurodegenerative disease worldwide with growing prevalence. MPTP is a neurotoxin which causes the appearance of Parkinson's disease (PD) pathology. The involvement of the cholinergic system in PD has been identified decades ago and anti-cholinergic drugs were upon the...

ORGANISM(S): Mus musculus

2012-01-09 | E-GEOD-31458 | biostudies-arrayexpress

RNA sequencing and proteomic profiling reveal alterations by MPTP in chronic stomach mucosal injury in tree shrew Chinese (Tupaia belangeri chinensis)

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that can cause gastrointestinal ulcers by affecting dopamine levels. Therefore, MPTP has been considered a toxic substance that causes gastric ulcer disease in experimental animals. In this study, tree shrews were used as the animal...

ORGANISM(S): Tupaia belangeri

2024-01-26 | PXD047458 | Pride

Transcription profiling of macaque prefrontal cortex treated with MPTP

MPTP treated Macaca fascicularis prefrontal cortices compared to saline treated and untreated controls Experiment Overall Design: Macaques injected daily with Experiment Overall Design: MPTP hydrochloride (0.2 mg/kg, or with saline. Each group consisted of

ORGANISM(S): Homo sapiens

2008-06-13 | E-GEOD-4550 | biostudies-arrayexpress

VTA neurons show an adaptive transcriptional response to MPTP which differs from SN neurons

Implications for neuroprotection in Parkinson's disease Parkinson’s disease and its characteristic symptoms are thought to arise from the progressive degeneration of specific midbrain dopamine (DA) neurons. In humans, DA neurons of the substantia nigra (SN) and their projections to the striatum sh...

ORGANISM(S): Mus musculus

2009-12-31 | E-GEOD-17542 | biostudies-arrayexpress

Gene expression data from thalamic regions of MPTP-intoxicated mouse brain by acupuncture

Acupuncture stimulations at GB34 and LR3 inhibit the reduction of tyrosine hydroxylase in the nigrostriatal dopaminergic neurons in the parkinsonism animal models. Especially, behavioral tests showed that acupuncture stimulations improved the motor dysfunction in a previous study. The thalamus is a ...

ORGANISM(S): Mus musculus

2012-01-18 | E-GEOD-35138 | biostudies-arrayexpress

Gene expression data from striatal regions of MPTP-intoxicated mouse brain by acupuncture

Acupuncture at acupoints GB34 and LR3 has been reported to inhibit nigrostriatal degeneration in parkinsonism models, yet the genes related to this preventive effect of acupuncture on the nigrostriatal dopaminergic system remain elusive. We investigated gene expression profile changes in the striata...

ORGANISM(S): Mus musculus

2010-10-23 | E-GEOD-24829 | biostudies-arrayexpress

Transcription profiling of mouse multiple brain regions for a MPTP model of Parkinsons disease

In Parkinsonâ??s disease (PD), the progressive loss of substantia nigra dopamine cells has been associated with their vulnerability to oxidative stress, inflammation, and mitochondrial dysfunction. To identify multiple gene transcription alterations that may potentially underlie early stages of rela...

ORGANISM(S): Mus musculus

2008-10-26 | E-GEOD-7707 | biostudies-arrayexpress

Proteomic analysis of Rasagiline

The effect of rasagiline or MPTP on midbrain protein expression profile

ORGANISM(S): Mus musculus

2010-06-05 | E-GEOD-1857 | biostudies-arrayexpress

Genes regulated in MPTP-treated macaques

PRJNA94467 | ENA

Gene expression data from cervical spinal cord regions of MPTP-intoxicated mouse by acupuncture

It has been shown that acupuncture at acupoints GB34 and LR3 inhibits the degeneration of nigrostriatal neurons in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinsonâ??s disease. This preventative effect of peripheral acupuncture stimulation is hypothesized to be transmi...

ORGANISM(S): Mus musculus

2010-10-23 | E-GEOD-24830 | biostudies-arrayexpress

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