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GenomicsTranscriptome expression study with chronological aging in human hippocampus
Transcriptome expression study with chronological aging in human hippocampus
PRJNA828461 | ENA
TranscriptomicsFunctional Comparison of Chronological and In Vitro Aging: Differential Role of the Cytoskeleton and Mitochondria in Mesenchymal Stromal Cells
Mesenchymal stromal cells (MSCs) are of high relevance for the regeneration of mesenchymal tissues such as bone and cartilage. The promising role of MSCs in cell-based therapies and tissue engineering appears to be limited due to a decline of their regenerative potential with increasing donor age, t...
ORGANISM(S): Rattus norvegicus 
2013-01-05 | E-GEOD-36596 | biostudies-arrayexpress
ProteomicsChronological mitochondrial proteomics of chemically induced hepatocellular carcinoma in rat
Although disruption of mitochondrial function has been associated with energetic deregulation in cancer, the chronological changes in mitochondria during cancer development remain unclear. With the aim to assess the role of mitochondria throughout cancer development, we analyzed samples chronologica...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-09 | PXD023388 | Pride
Omics integration Shotgun proteomics Rat Hepatocellular carcinoma Chronological study Mitochondria 
GenomicsEpigenetic determinants of muscle stem cell quiescence and chronological aging (ChIP-seq)
Skeletal muscle is a post-mitotic tissue that exhibits an extremely low turnover in the absence of disease or injury. At the same time, muscle possesses remarkable regenerative capacity mediated by satellite cells (SCs) that reside in close association with individual myofibers, underneath the fiber...
ORGANISM(S): Mus musculus 
2013-08-13 | E-GEOD-47362 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae (budding yeast) mutants reveals Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and programmed cell death
Changes in the transcriptome of Isc1p deficient mutants. The inositolphosphosphingolipid phospholipase C (Isc1p) of Saccharomyces cerevisiae belongs to the family of neutral sphingomyelinases that generates the bioactive sphingolipid ceramide. In this work the role of Isc1p in oxidative stress resis...
ORGANISM(S): Saccharomyces cerevisiae 
2008-02-05 | E-MEXP-1136 | biostudies-arrayexpress
TranscriptomicsTranscriptome expression study with chronological aging in human hippocampus
In our study, we performed a transcriptomic analysis from hippocampal samples from human individuals of different ages. We identified a set of genes that were differentially expressed in aged samples. Moreover, we revealed a subset of genes whose expression correlated with chronological aging. Analy...
ORGANISM(S): Homo sapiens 
2024-08-21 | GSE201118 | GEO
TranscriptomicsAging Experiment
Lifelong murine gene expression profiles in relation to chronological and biological aging in multiple organs Five tissues: Kidney, Liver, Lung, Spleen, Brain. Six timepoints: 13wks, 26 wks, 52wks, 78wks, 104wks, 130wks. One Genotype: C57Bl/6, 3 replicates
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-34378 | biostudies-arrayexpress
GenomicsBre1-mediated Set2 protein degradation promotes chronological aging in budding yeast [ChIP-seq]
Bre1-mediated Set2 protein degradation promotes chronological aging in budding yeast [ChIP-seq]
PRJNA912607 | ENA
ProteomicsProteomics of muscle chronological ageing in post-menopausal women
Background Muscle ageing contributes to both loss of functional autonomy and increased morbidity. Muscle atrophy accelerates after 50 years of age, but the mechanisms involved are complex and likely result from the alteration of a variety of interrelated functions. In order to better understand the ...
ORGANISM(S): Homo sapiens (Human) 
2015-02-19 | PXD001527 | Pride
Human Sarcopenia Skeletal muscle Proteomics Ageing Biomarkers 
GenomicsBre1-mediated Set2 protein degradation promotes chronological aging in budding yeast [RNA-seq]
Bre1-mediated Set2 protein degradation promotes chronological aging in budding yeast [RNA-seq]
PRJNA912608 | ENA
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