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ProteomicsOptimising a self-assembling peptide hydrogel as a Matrigel alternative for 3-dimensional mammary epithelial cell culture
Three-dimensional (3D) organoid models have been instrumental in understanding molecular mechanisms responsible for many cellular processes and diseases. However, established organic biomaterial scaffolds used for 3D hydrogel cultures, such as Matrigel, are biochemically complex and display signific...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD045193 | Pride
Mammary epithelial cell 3d Laminin Organoid 
TranscriptomicsFoxl1-Cre-marked Adult Hepatic Progenitors Have Clonogenic and Bi-Lineage Differentiation Potential - Time Course
The winged helix transcription factor Foxl1 is a marker for progenitor cells and their descendants in the mouse liver in vivo. Here, we purify progenitor cells from Foxl1-Cre; RosaYFP mice and evaluate their proliferative and differentiation potential in vitro. Treatment of Foxl1-Cre; RosaYFP mice w...
ORGANISM(S): Mus musculus 
2011-05-01 | E-GEOD-28890 | biostudies-arrayexpress
GenomicsHdac6 regulates Tip60-p400 function in stem cells (sequencing)
The Tip60 (also known as Kat5) lysine acetyltransferase functions broadly as a transcriptional co-activator that acetylates histones. In contrast, Tip60 functions in embryonic stem cells (ESCs) both to silence genes that promote differentiation and to activate genes required for proliferation. The m...
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-42209 | biostudies-arrayexpress
ProteomicsDistribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis.
Project aim was to identify protein-protein interactions of the post-translationally modified form of alpha-synuclein. In situ proximity labeling (BAR) was used to enrich for protein-protein interactions. We performed BAR on wild-type and alpha-synuclein knockout olfactory bulb tissues. We include n...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-27 | PXD040392 | Pride
Proteomics  neurodegeneration  vesicles  protein aggregation. 
UnknownAntibody evasion properties of SARS-CoV-2 Omicron sublineages.
Not available
S-EPMC9021018 | biostudies-literature
UnknownPreclinical Immunogenicity and Efficacy of Optimized O25b O-Antigen Glycoconjugates To Prevent MDR ST131 E. coli Infections.
Not available
S-EPMC9022517 | biostudies-literature
UnknownQuality of life in MAP.3 (Mammary Prevention 3): a randomized, placebo-controlled trial evaluating exemestane for prevention of breast cancer.
Not available
S-EPMC4879707 | biostudies-literature
ProteomicsEndophyte-promoted Phosphorous Fixation in Poplar
Studying the endophyte strains of poplar that help the plant solubilize phosphate, we observed direct evidence of endophyte-promoted phosphorous fixation. Using synchrotron x-ray fluorescence (SR-XRF) microscopy combined with x-ray absorption near-edge structure (XANES), we visualized the nutrient p...
ORGANISM(S): Populus Trichocarpa (ncbitaxon:3694) 
2020-01-29 | MSV000084860 | MassIVE
TranscriptomicsNiche-based screening identifies small-molecule inhibitors of leukemia stem cells
Efforts to develop more effective therapies for acute leukemia may benefit from high-throughput screening systems that reflect the complex physiology of the disease, including leukemia stem cells (LSCs) and supportive interactions with the bone-marrow microenvironment. The therapeutic targeting of L...
ORGANISM(S): Mus musculus 
2013-09-20 | E-GEOD-51033 | biostudies-arrayexpress
UnknownM2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance.
Not available
S-EPMC10628945 | biostudies-literature
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