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TranscriptomicsTranscription profiling of diaphragm muscles from alpha2-laminin (merosin)-deficient dy/dy dystrophic mice and wild type mice to study differential gene expression.
Laminin (merosin) deficient muscular dystrophy in dy/dy mouse diaphragm muscle, 8 weeks old Experiment Overall Design: 4 normal samples; 4 dystrophic samples; Each sample consists of muscle pooled from 3 mice, thus a total of 12 normal and 12 dystrophic mice were studied
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3252 | biostudies-arrayexpress
ProteomicsCross-linking of mouse laminin 111
Laminin, a ~800 kD heterotrimeric protein, is a major functional component of the extracellular matrix, contributing to tissue development and maintenance. We used cross-linking and mass spectrometry to determine the order of subunits in the ~750 Å trimeric coiled-coil oligomerization domain of lami...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-22 | PXD004898 | Pride
Cross linking Extra cellular matrix Laminin 
TranscriptomicsTLR 4 Signaling Inhibitory Pathway Induced by Green Tea Polyphenol Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor
Epigallocatechin-3-gallate (EGCG), a major active polyphenol of green tea, has been shown to downregulate inflammatory responses in macrophages; however, the underlying mechanism has not been understood. Recently, we identified the 67-kDa laminin receptor (67LR) as a cell-surface EGCG receptor that ...
ORGANISM(S): Mus musculus 
2010-04-20 | E-GEOD-21320 | biostudies-arrayexpress
ProteomicsLabel-free mass spectrometry analysis of laminin with induced oxidations and chlorination’s facilitated with hypochlorous acid and myeloperoxidase treatments.
Basement membranes are specialized extracellular matrices that underlie arterial wall endothelial cells, with laminin being a key structural and biologically-active component. Hypochlorous acid (HOCl), a potent oxidizing and chlorinating agent, is formed in vivo at sites of inflammation, via the enz...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-05 | PXD022056 | Pride
Ecm Lc-ms/ms Oxidation Extracellular matrix proteins Inflammation. Chlorination Laminin 
TranscriptomicsTranscription profiling of laminin binding and laminin non-binding germ cells to define the spermatogonial stem cells.
Comparison of laminin binding and laminin non-binding germ cells.
ORGANISM(S): Mus musculus 
2007-12-19 | E-GEOD-829 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of finite life span and immortal non-malignant human mammary epithelial cell lines
We analyzed gene expression in 184 (finite life span) and HMT3522 S1 (immortal non-malignant) HMECs on successive days (3, 5, and 7) post-seeding in a laminin-rich extracellular matrix assay. Both HMECs underwent growth arrest in G0/G1 and differentiated into polarized acini between days 5 and 7.
ORGANISM(S): Homo sapiens 
2007-03-15 | E-MEXP-1006 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mammary epithelial cell lines with finite life span and immortal non-malignant cells - time series
Nonmalignant human mammary epithelial cells (HMEC) seeded in laminin-rich extracellular matrix (lrECM) form polarized acini and, in doing so, transit from a disorganized proliferating state to an organized growth-arrested state. We hypothesized that the gene expression pattern of organized and growt...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-8096 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profile of mouse Lewis lung carcinoma LLC1 cell line cultivated in 2-dimensional or 3-dimensional cell culture enriched with laminin rich extracellular matrix proteins
The extracellular matrix (ECM), as one of the key components of tumor microenvironment has a high impact on cancer development and highly influences tumor cell features. ECM contribute not only structural support to growing tumor cells, but also affect other cellular functions such as cell different...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-75862 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse laminin alpha 2 chain deficient animals vs wild type
Mutations in the gene encoding laminin a2 chain cause congenital muscular dystrophy, MDC1A. In skeletal muscle, laminin a2 chain binds at least two receptor complexes; the dystrophin-glycoprotein complex and integrin a7b1. To gain insight into the molecular mechanisms underlying this disorder, we pe...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-12049 | biostudies-arrayexpress
TranscriptomicsGene expression profile of mouse Lewis lung carcinoma cell line cultivated in 2-dimensional or 3-dimensional cell culture enriched with laminin rich extracellular matrix proteins.
Obvious advantages of 3D cell culture model are the cell morphology better reflecting tissue cell morphology, the formation of zones of i) active proliferation, ii) quiescent viable cell zone and iii) necrotic zone, as well as formation of nutrition, oxygen and drug gradients better reflecting cellu...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-75863 | biostudies-arrayexpress
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