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TranscriptomicsAmplification of RANK- and c-Met-mediated signaling promotes metastatic colonization
We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-48432 | biostudies-arrayexpress
TranscriptomicsProfiling Chung rat model for neuropathic pain
This program addresses the gene signature associated with DRG in the Chung rat model for neuropathic pain. The Chung neuropathic pain profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in DRG of the Sprague Dawley rats following spin...
ORGANISM(S): Rattus norvegicus 
2013-03-22 | E-GEOD-38038 | biostudies-arrayexpress
TranscriptomicsHost and pathogen interaction: time course [C. albicans]
The interaction between fungal pathogen and host during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histological analysis of surviving fis...
ORGANISM(S): Candida albicans 
2013-08-26 | E-GEOD-32117 | biostudies-arrayexpress
ProteomicsThe Okur-Chung Neurodevelopmental Syndrome (OCNDS) mutation CK2K198R leads to a rewiring of kinase specificity
Okur-Chung Neurodevelopmental Syndrome (OCNDS) is caused by heterozygous mutations to the CSNK2A1 gene, which encodes the alpha subunit of casein kinase II (CK2). The most frequently occurring mutation is lysine 198 to arginine (K198R). To investigate the impact of this mutation, we first generated ...
ORGANISM(S): Escherichia coli 
2022-05-31 | PXD030823 | Pride
Ck2 Phosphorylation Okur-chung Ckii Kinase Phosphoproteomics Mutation Propel 
ProteomicsProtein-protein interactions of MEG-3 in C. elegans early embryos
We combined in vivo expressed GFP-tagged MEG-3 (GEI-12) with label-free quantitative proteomics to identify protein-protein interactions of MEG-3 in early C. elegans embryos.
ORGANISM(S): Caenorhabditis elegans 
2021-07-01 | PXD012852 | Pride
Ap-ms Early embryo Ppi Meg-3 C. elegans Gei-12 
UnknownEfficacy and Safety of Cystatin C-Guided Renal Dose Adjustment of Cefepime Treatment in Hospitalized Patients with Pneumonia.
Not available
S-EPMC7564664 | biostudies-literature
UnknownRefining the clinical phenotype of Okur-Chung neurodevelopmental syndrome.
Not available
S-EPMC5874396 | biostudies-literature
UnknownC-Glycoside-Metabolizing Human Gut Bacterium, Dorea sp. MRG-IFC3.
Not available
S-EPMC10772555 | biostudies-literature
UnknownPHIP variants associated with Chung-Jansen syndrome disrupt replication fork stability and genome integrity.
Not available
S-EPMC9528965 | biostudies-literature
TranscriptomicsExpression profiles of 186-gene signature in U.S. hepatitis C virus (HCV)-related liver cirrhosis
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54100 | biostudies-arrayexpress
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