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ProteomicsHEK293T LC-MSMS of DND1 immunoprecipitations
HEK293T interactomes of transiently expressed RNA-binding protein DND1: WT (replicates P9-1, P10-1, P18-1), R98A RNA binding mutant (replicates P9-2, P10-2, P18-2) and 1-235 dsRBD truncation mutant (replicates P9-3, P10-3, P18-3)
ORGANISM(S): Homo sapiens (Human) 
2022-05-30 | PXD024666 | Pride
Human Lc-msms Dnd1 Hek293t 
TranscriptomicsRestriction of LINE1 activity by RNAi correlates with mouse ES cell differentiation
Long interspersed elements 1 (LINE-1 or L1) are retrotransposons that dominate the mouse genomic landscape, and are expressed in Embryonic Stem Cells (ESCs), germ cells, and during early development. Based on clear precedents in plants and fission yeast, we investigated in this study a role for RNAi...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-43110 | biostudies-arrayexpress
TranscriptomicsDeep-sequencing influences the results obtained in small-RNA sequencing
This study presents a comparison of small RNA sequencing libraries generated from the same cell lines but using different sequencing platforms and protocols. The samples were analyzed and compared at the level of miRNAs expression and as a population of small RNAs derived from repetitive elements. D...
ORGANISM(S): Mus musculus 
2012-03-01 | E-GEOD-35368 | biostudies-arrayexpress
TranscriptomicsAntiviral RNA interference in mammalian cells
Plants and invertebrates protect themselves from viruses through RNA interference (RNAi), yet it remains unknown whether this defense mechanism exists in mammals. Antiviral RNAi involves the processing of viral long double-stranded (ds) RNA molecules into small interfering RNAs (siRNAs) by the ribon...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-43153 | biostudies-arrayexpress
TranscriptomicsHigh-throughput pyrosequencing of endogenous small RNAs from Arabidopsis thaliana wild-type and ddm1 mutant.
DNA methylation is essential for silencing transposable elements and some genes in higher eukaryotes, implying that this modification must be tightly controlled. However, accidental changes in DNA methylation can be transmitted through mitosis, as in cancer, or meiosis, leading to epiallelic variati...
ORGANISM(S): Arabidopsis thaliana 
2009-02-02 | E-GEOD-13419 | biostudies-arrayexpress
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