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Transcriptomicstranscriptional analysis of breast circadian clock
Circadian clocks drive ~24 hr rhythms in tissue physiology. They rely on transcriptional/translational feedback loops driven by interacting networks of clock complexes.To gain insights into the role of the mammary clock, circadian time-series microarrays were performed to identify rhythmic genes in ...
ORGANISM(S): Mus musculus 
2017-12-01 | E-MTAB-5330 | biostudies-arrayexpress
ProteomicsInteractome of the circadian clock protein PERIOD2 in human U2OS osteosarcoma cells after the resetting of the circadian clock
Circadian rhythms are a series of endogenous autonomous 24-hour oscillations generated by the circadian clock. At the molecular level, the circadian clock is generated by a transcription-translation feedback loop, where BMAL1 and CLOCK transcription factors of the positive arm activate the expressio...
ORGANISM(S): Homo sapiens (Human) 
2022-04-22 | PXD025179 | Pride
Protein−protein interactions Proteomics Period2 Circadian clock Bioid 
Transcriptomicscircadian clock in cartilage
This experiment investigated the circadian clock in mice cartilage. A microarray time-series was performed using xiphoid tissue (metasternum) from mice in constant darkness. Time points were every 4 hr for 40 hr in total.
ORGANISM(S): Mus musculus 
2013-10-19 | E-MEXP-3780 | biostudies-arrayexpress
MetabolomicsClock regulation of metabolites reveals coupling between transcription and metabolism
The circadian clock is intricately connected with metabolism, however the precise details of these connections are incomplete. Here we used high temporal resolution metabolite profiling to determine circadian regulation of mouse liver and cell autonomous metabolism. In mouse liver, we found ~50% of ...
2017-04-05 | MTBLS292 | MetaboLights
ProteomicsDirect evaluation of metabolic rhythms from quantitative circadian proteomics revealed rampant post-transcriptional regulation by Chlamydomonas clock
Temporal dynamics in an organism's behavior, physiology, metabolism, and biochemistry over the course of 24 hours are governed by an inherent cellular clock. Transcriptomic studies revealed that the clock is governed by intricate transcriptional and translational feedback loops(TTFLs) involving dail...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-05-27 | PXD043839 | Pride
Post-transcriptional regulations Swath-ms Proteomics C. reinhardtii Circadian clock 
UnknownSubtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis.
Not available
S-EPMC10245642 | biostudies-literature
ProteomicsMouse SCN in LC-MSMS - The suprachiasmatic nucleus (SCN) acts as the central clock to coordinate circadian oscillations in mammalian behavior, physiology and gene expression. Despite our knowledge of the circadian transcriptome of the SCN, how it impacts genome-wide protein expression is not well understood. Here, we interrogated the murine SCN proteome across the circadian cycle using SILAC-based quantitative mass spectrometry.
The suprachiasmatic nucleus (SCN) acts as the central clock to coordinate circadian oscillations in mammalian behavior, physiology and gene expression. Despite our knowledge of the circadian transcriptome of the SCN, how it impacts genome-wide protein expression is not well understood. Here, we inte...
ORGANISM(S): Mus musculus (Mouse) 
2014-09-10 | PXD000778 | Pride
Circadian rhythm Mouse Suprachiasmatic nucleus Lc-ms/ms 
ProteomicsData-independent acquisition method for ubiquitinome analysis reveals non-degrative regulation of circadian biology
Protein ubiquitination is involved in virtually all cellular processes. Enrichment strategies employing antibodies targeting ubiquitin-derived diGly remnants combined with mass spectrometry (MS) have enabled investigations of ubiquitin signaling at a large scale. However, so far the power of data in...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD019854 | Pride
Circadian biology Dia 
GenomicsProbing Genetics and Biology of Human Circadian Function
Probing Genetics and Biology of Human Circadian Function
PRJNA821595 | ENA
ProteomicsCircadian Rhythms in Cyanobacterial Protein Condensation
Circadian rhythms are endogenously generated daily cycles in physiology that are closely tied to metabolism and can be found in all kingdoms of life. In cyanobacteria, energy storage through glycogen metabolism is highly rhythmic, but the underlying mechanisms remain unclear. Here we find that the g...
ORGANISM(S): Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) Bacteria 
2026-05-25 | PXD074299 | Pride
Circadian Cyanobacteria 
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