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MetabolomicsCircadian disruption exacerbates MASH in mice by reducing intestinal Akkermansia muciniphila abundance via the FXR-CYP7A1-bile acid axis_Targeting Bile Acids

Circadian disruption has emerged as a significant public health issue and is increasingly recognized as a contributor to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), though the underlying mechanisms remain poorly understood. In this study, we established a ...

2026-02-05 | MTBLS13845 | MetaboLights
MetabolomicsCircadian disruption exacerbates MASH in mice by reducing intestinal Akkermansia muciniphila abundance via the FXR-CYP7A1-bile acid axis_Targeting Bile Acids_Untargeted Serum Metabolomics

Circadian disruption has emerged as a significant public health issue and is increasingly recognized as a contributor to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), though the underlying mechanisms remain poorly understood. In this study, we established a ...

2026-02-05 | MTBLS13848 | MetaboLights
TranscriptomicsMH003A:FOXO3 in control of circadian rhythms via direct regulation of Clock. Part 1: overexpression of FoxO6
Circadian rhythms are responsive to a variety of external cues, light and metabolism being the most important. In mammals, the light signal is sensed by the retina and transmitted to the SCN master clock, where it is translated into the molecular oscillator via regulation of clock gene transcription...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-41554 | biostudies-arrayexpress
TranscriptomicsMH003B:FOXO3 in control of circadian rhythms via direct regulation of Clock. Part 2: knockdown of FoxO3.
Circadian rhythms are responsive to a variety of external cues, light and metabolism being the most important. In mammals, the light signal is sensed by the retina and transmitted to the SCN master clock, where it is translated into the molecular oscillator via regulation of clock gene transcription...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-41555 | biostudies-arrayexpress
TranscriptomicsCircadian transcriptional profiling of peritoneal macrophages
In the immune system various parameters and immune functions are controlled by the circadian system. To investigate molecular mechanisms that link the circadian clock and the immune system we analyzed the transcriptom of peritoneal macrophages from mice collected in a time course for two consecutive...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-25585 | biostudies-arrayexpress
ProteomicsPhenotypic Proteomic Profiling Reveals Convergent Kinase Targets for Circadian Clock Modulators
Determining the mechanisms of action of drug molecules that modulate circadian rhythms is critical to develop novel compounds to treat clock disorders. Here we employed Phenotypic Proteomic Profiling (PPP) integrating multipronged proteomics approaches including global proteome, phosphoproteome, kin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD014186 | Pride
Circadian rhythms  circadian period altering compounds  kinase  phenotypic proteome profiling  phosphoproteome  proteomics  thermal proteome profiling 
TranscriptomicsSex-related differences in gene expression following Coxiella burnetii infection: potential role of circadian rhythm
Q fever, a zoonosis due to Coxiella burnetii infection, exhibits sexual dimorphism; men are affected more frequently and severely than women for a given exposure. Here we explore whether the severity of C. burnetii infection in mice is related to differences in male and female gene expression profil...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-21065 | biostudies-arrayexpress
TranscriptomicsIdentification of circadian transcripts that are co-regulated with [Ca2+]cyt
Our aim is to identify circadian transcripts that are co-regulated with [Ca2+]cyt, with the eventual goal of identifying genetic regulators and targets for circadian oscillations of [Ca2+]cyt. We have identified two conditions in which [Ca2+]cyt behaves differently to other circadian outputs. 1. ...
ORGANISM(S): Arabidopsis thaliana 
2009-12-09 | E-GEOD-19271 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis to identify of circadian-regulated genes
Most higher organisms, including plants and animals, have developed a time-keeping mechanism that allows them to anticipate daily fluctuations of environmental parameters such as light and temperature. This circadian clock efficiently coordinates plant growth and metabolism with respect to time-of-...
ORGANISM(S): Arabidopsis thaliana 
2008-06-17 | E-GEOD-8365 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of circadian transcript expression in mature soil-grown Arabidopsis thaliana plants
Microarray analysis of circadian transcript expression in mature soil-grown Arabidopsis thaliana plants.
ORGANISM(S): Arabidopsis thaliana 
2007-09-18 | E-TABM-331 | biostudies-arrayexpress
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