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GenomicsCircTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene Tulp4
CircTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene Tulp4
PRJEB42003 | ENA
TranscriptomicsCircTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene Tulp4
Here, we systematically investigated circRNAs in the APP/PS1 model mouse brain through deep RNA-sequencing. We report that circRNAs are markedly enriched in the brain and that several circRNAs exhibit differential expression between wild-type and APP/PS1 mice. We characterized one abundant circRNA, ...
ORGANISM(S): Mus musculus 
2021-02-28 | E-MTAB-9919 | biostudies-arrayexpress
ProteomicsA brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli
The biological significance of circular RNAs remains largely unexplored due to the lack of loss-of-function animal models. In this study, we focused on circTulp4, a highly abundant circRNA that is enriched in the brain and synaptic compartments. We created a circTulp4-deficient (CD) mouse model and ...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD045787 | Pride
Synaptosomes Label-free proteomics Mass spectrometry Circtulp4 Phenotyping Neurophysiology Circular rna 
TranscriptomicsA brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli
Circular RNAs are a large class of non-coding RNAs present in all eukaryotic taxa. Despite the identification of thousands of circular transcripts, the biological significance of most of them remains largely unexplored, partly due to the lack of effective methods for generating loss-of-function anim...
ORGANISM(S): Mus musculus 
2024-04-13 | GSE246304 | GEO
UnknownA brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli.
Not available
S-EPMC11122670 | biostudies-literature
UnknownRETRACTED: circTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene, Tulp4
Not available
S-EPMC8178447 | biostudies-literature
UnknownThe Circular RNome of Developmental Retina in Mice.
Not available
S-EPMC6938940 | biostudies-literature
GenomicsA brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli
A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli
PRJNA1032476 | ENA
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