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ProteomicsThe conserved NUS-1/DHDDS-1 complex links N-glycosylation to lipid and lysosomal homeostasis in C. elegans
Using the nematode Caenorhabditis elegans as a model animal system, this study aims to investigate and elucidate the detailed pathogenic mechanisms by which mutations in the cis-prenyltransferase (cis-PT) complex, which plays an essential role in the human N-glycosylation pathway, lead to the develo...
ORGANISM(S): Caenorhabditis elegans 
2026-09-25 | PXD084420 | Pride
C. elegans Cis-pt 
UnknownPhotoinduced reactions of cis,trans,cis-[Pt(IV)(N3)2(OH)2(NH3)2) with 1-methylimidazole.
Not available
S-EPMC2935676 | biostudies-literature
GenomicsHepatocyte Nuclear Factors 4a and 1a (Hnf4a and Hnf1a) Regulate Kidney Developmental Expression of Drug-Metabolizing Enzymes and Drug Transporters
The transcriptional regulation of drug-metabolizing enzymes and transporters (here collectively referred to as DMEs) in the developing proximal tubule is not well understood. As in the liver, DME regulation in the PT may be mediated through nuclear receptors which are thought to “sense” deviations f...
ORGANISM(S): Rattus norvegicus 
2014-01-01 | E-GEOD-50815 | biostudies-arrayexpress
UnknownNovel cis-Pt(II) Complexes with Alkylpyrazole Ligands: Synthesis, Characterization, and Unusual Mode of Anticancer Action.
Not available
S-EPMC8906972 | biostudies-literature
UnknownStereoselective self-assembly of cis- and trans- [Pt<sub>2</sub>L<sub>2</sub>] metallacycles via geometrically-asymmetric 90<sup>o</sup> Pt(II) acceptors.
Not available
S-EPMC12748632 | biostudies-literature
Unknowncis/trans-[Pt(C∧N)(C≡CR)(CNBut)] Isomers: Synthesis, Photophysical, DFT Studies, and Chemosensory Behavior.
Not available
S-EPMC10394665 | biostudies-literature
ProteomicsStructural mechanisms of allosteric regulation in the human cis-prenyltransferase complex
Human cis-prenyltransferase (hcis-PT) synthesizes long-chain isoprenoids essential for N-linked protein glycosylation. This heteromeric complex comprises the catalytic subunit DHDDS and the regulatory Nogo-B receptor (NgBR). Although NgBR dramatically enhances DHDDS activity, the molecular basis for...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD063722 | Pride
Nogo-b receptor Allosteric regulation Dehydrodolichyl diphosphate synthase Cis-prenyltransferase Dhdds N-linked glycosylation Molecular dynamics simulations Hydrogen-deuterium exchange mass spectrometry Network analysis Ngbr 
ProteomicsStructural analysis of human cis-prenyltransferase
Isoprenoids are synthesized by the prenyltransferases superfamily, which is subdivided according to the product stereoisomerism and length. In short- and medium-chain isoprenoids, product length correlates with active site volume. However, enzymes synthesizing long-chain products and rubber synthase...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD031707 | Pride
Cis-prenyltransferase H/d exchange mass spectrometry Isoprenoid synthesis 
TranscriptomicsDirect androgen receptor regulation of sexually dimorphic gene expression in the mammalian kidney
Mammalian organs exhibit distinct physiology, disease susceptibility and injury responses between the sexes. In the mouse kidney, sexually dimorphic gene activity maps predominantly to proximal tubule (PT) segments. Bulk RNA-seq data analyses demonstrated sex differences were established from 4 and ...
ORGANISM(S): Mus musculus 
2023-08-02 | GSE225566 | GEO
TranscriptomicsSingle-cell RNA Sequencing of Wild Type and Cisplatin Induced AKI (3d and 7d groups) Mouse Kidney
Purpose: By using single-cell RNA sequencing to reveal the heterogeneity and dynamic variation of immune cell subsets in kidney injury and repairment phases Methods: 10×Genomic single-cell RNA sequencing at Sham, day 3 and day 7 time points of murine model of cisplatin induced AKI were conducted to ...
ORGANISM(S): Mus musculus 
2026-07-01 | GSE179807 | GEO
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