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MetabolomicsElevated lysophosphatidylcholines during SSRI-induced neural differentiation correlate with early neurodevelopmental symptoms

Background: Selective serotonin reuptake inhibitors (SSRIs) are often prescribed during pregnancy. Yet, epidemiological studies link in-utero SSRI exposure with neurodevelopmental disorders, such as autism and ADHD. The potential molecular mechanisms by which SSRIs impact early n...

2026-04-02 | MTBLS12645 | MetaboLights
GenomicsThe effects of ifosfamide and citalopram on developing zebrafish
The effects of ifosfamide and citalopram on developing zebrafish
PRJNA901165 | ENA
TranscriptomicsEpigenetic effects of antidepressants to neuroprotective genes in neuronal cultured cells
Antidepressants are widely used for treatment of depression. Imipramine, a typical antidepressant, is recently known to have an effect to restore the expression of brain-derived neurotrophic factor gene, which is decreased in depressed patients, by increasing histone acetylation. However, it is larg...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-63005 | biostudies-arrayexpress
GenomicsGene expression analysis of hESCs undergoing neuronal differentiation exposed to citalopram
Gene expression analysis of hESCs undergoing neuronal differentiation exposed to citalopram
PRJNA1083921 | ENA
TranscriptomicsEffects of Citalopram Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts
Recently, serotonin and serotonin reuptake inhibitor (SSRI) drugs have been shown to have an effect on the development and maintenance of bone. However, little is known about its role in craniofacial development. We used microarray as one tool to determine the gene expression profile of intramembran...
ORGANISM(S): Mus musculus 
2013-06-19 | E-GEOD-48057 | biostudies-arrayexpress
GenomicsPersistent and Dose-Dependent Neural and Metabolic Gene Expression Changes Induced by Transient Citalopram Exposure in Zebrafish
Persistent and Dose-Dependent Neural and Metabolic Gene Expression Changes Induced by Transient Citalopram Exposure in Zebrafish
PRJNA1332604 | ENA
GenomicsTranscriptome profiles of mouse cortical cultures and the brain treated with fluoxetine, sertraline or citalopram
Transcriptome profiles of mouse cortical cultures and the brain treated with fluoxetine, sertraline or citalopram
PRJNA1242215 | ENA
TranscriptomicsPersistent and Dose-Dependent Neural and Metabolic Gene Expression Changes Induced by Transient Citalopram Exposure in Zebrafish
Citalopram, a common selective serotonin reuptake inhibitor (SSRI), has been increasingly detected in aquatic environments due to ineffective removal and improper disposal. Although developmental exposure to SSRIs is linked to neurotoxicity, little is known about the persistence of gene expression a...
ORGANISM(S): Danio rerio 
2025-12-17 | GSE308723 | GEO
TranscriptomicsEffects of Citalopram Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts
Recently, serotonin and serotonin reuptake inhibitor (SSRI) drugs have been shown to have an effect on the development and maintenance of bone. However, little is known about its role in craniofacial development. We used microarray as one tool to determine the gene expression profile of intramembran...
ORGANISM(S): Mus musculus 
2013-06-19 | GSE48057 | GEO
TranscriptomicsGene expression analysis of hESCs undergoing neuronal differentiation exposed to citalopram
Genome-wide gene expression profiling of human embryonic stem cells (hESCs) undergoing neuronal differentiation at four distinct time-points. hESCs are differentiated towards neuronal cells for 13 days, and sampled for downstream analysis at day 0, 6, 10 and 13 . Cells exposed to 50, 100, 200 and 40...
ORGANISM(S): Homo sapiens 
2024-07-01 | GSE260888 | GEO
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