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MetabolomicsMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, ...
2021-03-05 | MTBLS2159 | MetaboLights
MetabolomicsProtein lactylation of citrate synthase promotes the AKI–CKD transition by activating the NLRP3 inflammasome.

Interstitial renal inflammation contributes to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Recently, protein lactylation modification has emerged as a novel mechanism for mediating chronic organ damage. We investigated lactylated protein profiles and the role of...

2025-06-17 | MTBLS12606 | MetaboLights
MetabolomicsCitrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus

Pathogenic bacteria's metabolic adaptation for survival and proliferation within hosts is a crucial aspect of bacterial pathogenesis. Here, we demonstrate that citrate, the first intermediate of the tricarboxylic acid (TCA) cycle, plays a key role as a regulator of gene expression in Staphylococc...

2024-04-26 | MTBLS4276 | MetaboLights
MetabolomicsGlutaminolysis contribution to the carbon backbone of aspartate through ATP Citrate Lyase (ACLY) in ccRCC
Not available
ORGANISM(S): Homo sapiens 
ST002221 | MetabolomicsWorkbench
ProteomicsEscherichia coli S2P family intramembrane protease RseP is engaged in the regulated sequential cleavages of FecR in the ferric citrate signaling
Escherichia coli RseP, a member of the S2P family intramembrane proteases, is involved in the activation of the σE extracytoplasmic stress response and the elimination of remnant signal peptides. It remains however unclear whether RseP has additional cellular functions. In this study, we attempted t...
ORGANISM(S): Escherichia Coli 
2021-04-14 | PXD023797 | JPOST Repository
TranscriptomicsIron regulation in P. syringae DC3000
DC3000 cultures were grown under highly controlled conditions and after the addition of iron citrate or sodium citrate to the media. In the cultures supplemented with iron, we found that cell-associated iron increased rapidly while culture densities were not significantly different over 4 hours when...
ORGANISM(S): Pseudomonas syringae pv. tomato str. DC3000 
2008-11-07 | E-GEOD-13500 | biostudies-arrayexpress
GenomicsAnaplasma capra strain:citrate synthase (gltA) | isolate:Turkey_goat_135
Anaplasma capra strain:citrate synthase (gltA) | isolate:Turkey_goat_135 Genome sequencing
PRJNA948798 | ENA
GenomicsSelective autophagic degradation of ATP citrate lyase maintains citrate homeostasis and promotes oocyte maturation
Selective autophagic degradation of ATP citrate lyase maintains citrate homeostasis and promotes oocyte maturation
PRJNA787974 | ENA
ProteomicsATP-Citrate lyase fuels axonal transport across species
Microtubule (MT)-based transport is an evolutionary conserved processed finely tuned by posttranslational modifications. Among them, tubulin acetylation, which is catalyzed by the α-tubulin N-acetyltransferase 1, Atat1, facilitates the recruitment and processivity of molecular motors along MT tracks...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD021186 | Pride
Citrate Transport 
TranscriptomicsTranscription profiling of Arabidopis leaves treated with organic acids
Exogenous supply of citrate and malate to Arabidopsis leaves to monitor transcriptional changes resulting from these treatments.
ORGANISM(S): Arabidopsis thaliana 
2013-03-25 | E-MEXP-3110 | biostudies-arrayexpress
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