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MetabolomicsMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, ...
2021-03-05 | MTBLS2159 | MetaboLights
MetabolomicsMetabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
In vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to be more biologically relevant, or to optimise growth, is traditionally a laborious task. Emerging metabolomics technology enables rapid evaluation of ...
2015-05-14 | MTBLS49 | MetaboLights
MetabolomicsProtein lactylation of citrate synthase promotes the AKI–CKD transition by activating the NLRP3 inflammasome.

Interstitial renal inflammation contributes to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Recently, protein lactylation modification has emerged as a novel mechanism for mediating chronic organ damage. We investigated lactylated protein profiles and the role of...

2025-06-17 | MTBLS12606 | MetaboLights
MetabolomicsCitrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus

Pathogenic bacteria's metabolic adaptation for survival and proliferation within hosts is a crucial aspect of bacterial pathogenesis. Here, we demonstrate that citrate, the first intermediate of the tricarboxylic acid (TCA) cycle, plays a key role as a regulator of gene expression in Staphylococc...

2024-04-26 | MTBLS4276 | MetaboLights
TranscriptomicsIron regulation in P. syringae DC3000
DC3000 cultures were grown under highly controlled conditions and after the addition of iron citrate or sodium citrate to the media. In the cultures supplemented with iron, we found that cell-associated iron increased rapidly while culture densities were not significantly different over 4 hours when...
ORGANISM(S): Pseudomonas syringae pv. tomato str. DC3000 
2008-11-07 | E-GEOD-13500 | biostudies-arrayexpress
ProteomicsThe effect of citrate supplementation on medium viscosity and poly-γ-glutamic acid synthesis by engineered B. subtilis 168
The industrially attractive biopolymer Poly-γ-glutamic acid (γ-PGA) is commonly produced by species of the genus Bacillus by co-feeding different carbon- and nitrogen sources. Recent studies have highlighted the pivotal role of co-metabolization of a rapidly degradable carbon source such as glycerol...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2025-02-10 | PXD058048 | Pride
Vimos (viscosity monitoring online system) Γ-pga Viscosity Catabolite repression Biopolymer Bacillus subtilis Co-feed 
Transcriptomicscitrate vs nitrate Reducing cultures
The effect of nitrate reduction (anaerobic cultivation in the presence of heme, vitamin K2 and nitrate) was compared with anaerobic cultivation supplemented with citrate (Lactobacillus plantarum). The medium was chemically defined medium with mannitol as main carbon source Two-condition experiment, ...
ORGANISM(S): Lactobacillus plantarum 
2010-05-16 | E-GEOD-18339 | biostudies-arrayexpress
MetabolomicsSIRM Analysis of human P493 cells under hypoxia in [U-13C] labeled Glucose medium
Not available
ORGANISM(S): Homo sapiens 
ST000114 | MetabolomicsWorkbench
TranscriptomicsS. oneidensis MR-1 with electrode, Fe(III)citrate and oxygen as electron acceptor
S. oneidensis MR-1 was grown with different electron acceptors: an electrode at 0.4 V vs. SHE, 50 mM Fe(III)citrate, and oxygen. The gene expression pattern for each experiment was analyzed and the differences in gene expression for the different experimental conditions were compared. For two sample...
ORGANISM(S): Shewanella oneidensis MR-1 
2011-02-01 | E-GEOD-20379 | biostudies-arrayexpress
UnknownUse of regional citrate anticoagulation with medium cut-off membrane: pilot report.
Not available
S-EPMC9615209 | biostudies-literature
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