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TranscriptomicsGenetic regulation of human adipose microRNA expression and its consequences for metabolic traits
The genetics of messenger RNA expression has been extensively studied in humans and other organisms, but little is known about genetic factors contributing to microRNA (miRNA) expression. We examined natural variation of miRNA expression in adipose tissue in a population of 200 men who have been car...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-45159 | biostudies-arrayexpress
UnknownSystems genetics analysis of human body fat distribution genes identifies adipocyte processes.
Not available
S-EPMC11068934 | biostudies-literature
TranscriptomicsTranscription profiling of pig endothelium from multiple sites of coronary and non-coronary arteries
This study investigates the role of endothelial cell (EC) gene expression in the focal origin of atherosclerosis. The EC transcriptome was profiled in multiple arterial regions of normal swine. Specifically, small amounts of EC RNA were isolated from 7 athero-susceptible and 6 athero-protected regio...
ORGANISM(S): Sus scrofa 
2009-05-28 | E-CBIL-42 | biostudies-arrayexpress
TranscriptomicsEndothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis
While much progress has been made in identifying the mechanisms that trigger endothelial activation and inflammatory cell recruitment during atherosclerosis, less is known about the intrinsic pathways that counteract these events. Here we identified NOTCH1 as an antagonist of endothelial cell activa...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-72633 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pig reveals brief hypercholesterolemia induces changes in pig aortic endothelia
Hypercholesterolemia Study
ORGANISM(S): Sus scrofa 
2009-10-01 | E-CBIL-43 | biostudies-arrayexpress
GenomicsGenetic Variation Determines PPARγ Function and Antidiabetic Drug Response In Vivo [ChIP-seq]
SNPs affecting disease risk often reside in non-coding genomic regions. Here we show that SNPs are highly enriched at mouse strain-selective adipose tissue binding sites for PPARγ, a nuclear receptor for antidiabetic drugs. Many such SNPs alter binding motifs for PPARγ or cooperating factors, and fu...
ORGANISM(S): Homo sapiens 
2015-07-02 | E-GEOD-64458 | biostudies-arrayexpress
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