Ck19 - OmicsDI

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Enriched phosphopeptides were loaded onto a 50 cm EN C18 PepMap column with elution over a 1 h acquisition driven by a Waters mClass nanoUPLC. Eluted peptides were measured using a Thermo Orbitrap Fusion Tribrid mass spectrometer, with MS spectra acquired in the Orbitrap and MS2 spectra acquired in parallel, following HCD fragmentation, in the linear ion trap. (1)
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Treachery of hepatic protector triggers Notch signaling to promote hepatocyte-originated cholangiocarcinoma

Here, we found mesencephalic astrocyte-derived neurotrophic factor (MANF), a hepatic protector, was upregulated in human ICC tissues and sleeping beauty transposon (SBT) or thioacetamide (TAA)-induced mice ICC tissues. We verified the oncogenic role of MANF in ICC using cell lines overexpressing/kno...

ORGANISM(S): Homo sapiens (Human)

2025-08-25 | PXD048451 | Pride