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GenomicsCK2 regulates transcriptional elongation
CK2 binds to actively transcribed regions in the genome and regulates transcriptional elongation. Identification of genome-wide binding sites of CK2?, and examination of the effect of Pol II binding upon CK2 inhibition in LNCaP cells
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-58607 | biostudies-arrayexpress
ProteomicsSubstrate selectivity for semisynthetic CK2 proteins with Pin1
Protein Ser/Thr kinase CK2 is involved in a myriad of cellular processes including cell growth and proliferation by phosphorylating hundreds of substrates, yet the regulation process of CK2 function is poorly understood. The CK2 catalytic subunit, CK2α, is phosphorylated at Thr344 and phosphorylati...
ORGANISM(S): synthetic construct 
2011-10-24 | E-GEOD-33150 | biostudies-arrayexpress
ProteomicsSubstrate selectivity for semisynthetic CK2 proteins with various posttranslational modifications
Protein Ser/Thr kinase CK2 is involved in a myriad of cellular processes including cell growth and proliferation by phosphorylating hundreds of substrates, yet the regulation process of CK2 function is poorly understood. The CK2 catalytic subunit, CK2α, is modified by O-GlcNAc on Ser347 proximal to...
ORGANISM(S): synthetic construct 
2011-10-24 | E-GEOD-33149 | biostudies-arrayexpress
TranscriptomicsRegulation of DNA methylation by CK2-mediated phosphorylation of DNMT3A (Beadchip)
DNA methylation is a central epigenetic modification that has essential roles in cellular processes including chromatin structure, gene regulation, development and disease. The de novo DNA methyltransferases are responsible for the generation of genomic methylation patterns, but the underlying mecha...
ORGANISM(S): Homo sapiens 
2014-07-17 | E-GEOD-26164 | biostudies-arrayexpress
ProteomicsA Specific RAGE Phosphorylation by CK2 in human Amniotic Epithelial cell model
The receptor for advanced glycation end products (RAGE) is a multiligand, immunoglobulin-like transmembrane protein expressed in various cell types and implicated in a broad spectrum of diseases linked with epithelial dysfunctions. Despite significant progress in structural studies, the details of i...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD064008 | Pride
Rage / ck2 / phosphorylation 
ProteomicsMouse adipocyte phosphoproteome during differentiation
Kosaku Shinoda, Kana Ohyama, Yutaka Hasegawa, Hsin-Yi Chang, David W. Scheel, Louis Z. Sharp, Haemin Hong, Takashi Hosono, Mayu Ogura, Ayaka Sato, Yasushi Ishihama, and Shingo Kajimura. Phosphoproteomics Identifies CK2 As a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-08-28 | MSV000079278 | MassIVE
ProteomicsDNA mismatch repair activity of MutLα is regulated by CK2-dependent phosphorylation of MLH1 (S477)
MutLα, a heterodimer consisting of MLH1 and PMS2, is a key player of DNA mismatch repair (MMR), yet little is known about its regulation. In this study, we used mass spectrometry to identify phosphorylated residues within MLH1 and PMS2. The most frequently detected phosphorylated amino acid was seri...
ORGANISM(S): Homo sapiens (Human) 
2018-08-28 | PXD009524 | Pride
Ck2 Phosphorylation Lynch syndrome Dna mismatch repair Mutlα Mlh1 
TranscriptomicsA Common Docking (CD) Domain in Progesterone Receptor-B Links MKP3-Dependent Rapid Signaling Events to JAK/STAT Regulation of Gene Expression Required for Breast Cancer Cell Proliferation
Progesterone receptors (PRs) are critical context-dependent transcription factors required for normal uterine (PR-A) and mammary gland (PR-B) development. Progesterone is proliferative in the breast, where PR-target genes include paracrine factors that mediate mammary stem cell self-renewal. In the ...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-46850 | biostudies-arrayexpress
GenomicsCK2 phosphorylation of cap methyltransferase CMTR1 promotes RNAPII interaction
CK2 phosphorylation of cap methyltransferase CMTR1 promotes RNAPII interaction
PRJNA823002 | ENA
ProteomicsThe Okur-Chung Neurodevelopmental Syndrome (OCNDS) mutation CK2K198R leads to a rewiring of kinase specificity
Okur-Chung Neurodevelopmental Syndrome (OCNDS) is caused by heterozygous mutations to the CSNK2A1 gene, which encodes the alpha subunit of casein kinase II (CK2). The most frequently occurring mutation is lysine 198 to arginine (K198R). To investigate the impact of this mutation, we first generated ...
ORGANISM(S): Escherichia coli 
2022-05-31 | PXD030823 | Pride
Ck2 Phosphorylation Okur-chung Ckii Kinase Phosphoproteomics Mutation Propel 
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