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GenomicsCla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/CCdh1 complex
Cla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/CCdh1 complex
PRJNA1000592 | ENA
GenomicsCla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/CCdh1 complex
The expression of chromatin modifying enzymes needs to be tightly controlled to ensure proper distribution of chromatin modifications. H3 lysine 4 trimethylation (H3K4me3) is a conserved histone modification catalyzed by histone methyltransferase Set1 and its dysregulation is associated with patholo...
ORGANISM(S): Saccharomyces cerevisiae 
2023-10-18 | GSE239705 | GEO
ProteomicsCla4 catalyzed Set1 phosphorylation
H3K4me3 is catalyzed by the Set1/MLL family of methyltransferases, whose function in catalyzing H3K4me3 is unique. Impaired function of Set1/MLL family members can lead to many abnormalities, such as bone and nerve defects, leukemia, and even death. Although the Set1 family plays an important regula...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-10-24 | PXD042010 | Pride
Cla4 set1 phosphorylation 
Unknownp21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae.
Not available
S-EPMC2669209 | biostudies-literature
UnknownCla4 kinase triggers destruction of the Rac1-GEF Cdc24 during polarized growth in Ustilago maydis.
Not available
S-EPMC3164470 | biostudies-literature
UnknownCla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/CCdh1 complex.
Not available
S-EPMC10541012 | biostudies-literature
UnknownThe Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway.
Not available
S-EPMC2777111 | biostudies-literature
GenomicsChIP Seq Analysis of H3K4me3 in Wild Type and Set1 S228A S228E mutants
Cells need to coordinate gene expression with their metabolic states to maintain cell homeostasis and growth. However, how cells transduce nutrient availability to appropriate gene expression response via histone modifications remains poorly understood. Here,we reported cla4 catalyzed Set1 phosphory...
ORGANISM(S): Saccharomyces cerevisiae 
2023-10-18 | GSE229516 | GEO
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Set1 S228A S228E mutant Transcriptomes
Cells need to coordinate gene expression with their metabolic states to maintain cell homeostasis and growth. However, how cells transduce nutrient availability to appropriate gene expression response via histone modifications remains poorly understood. Here,we reported cla4 catalyzed Set1 phosphory...
ORGANISM(S): Saccharomyces cerevisiae S288C 
2023-10-18 | GSE208095 | GEO
ProteomicsSILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding yeast.
Protein phosphatase 2A (PP2A) is a family of conserved serine/threonine phosphatases involved in several essential aspects of cell growth and proliferation. PP2ACdc55 phosphatase has been extensively related to cell cycle events in budding yeast, however few PP2ACdc55 substrates have been identified...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-04-16 | PXD007613 | Pride
Pkc1 Mob1. Mitotic exit network (men) Pp2acdc55 phosphatase Cla4 
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