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TranscriptomicsHypoxia-induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling
Hypoxia (low oxygen) and Notch signaling are two important regulators of vascular development, but how they interact in controlling the choice between arterial and venous fates for endothelial cells during vasculogenesis is less well understood. In this report, we show that hypoxia and Notch signali...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-35894 | biostudies-arrayexpress
TranscriptomicsExpression data from isolated peritoneal macrophages treated with Histidine-rich glycoprotein
Histidine-rich glycoprotein (HRG) is a 75 kDa heparin-binding plasma protein which has been implicated in regulation of tumor angiogenesis and growth. To exert some of its biological functions, HRG acts on macrophages.This study was performed to assess changes in gene expression in peritoneal macrop...
ORGANISM(S): Mus musculus 
2011-12-06 | E-GEOD-34164 | biostudies-arrayexpress
TranscriptomicsVEGFR2 Y949F (lung RNAseq - mice)
RNA sequencing of lung tissue from transgenic mice in order to investigate the effect of a single tyrosine to phenylalanine exchange in the endothelial receptor VEGFR2 at position Y949. This exchange creates a mouse with unleaky blood vessels which is an advantage in several diseases such as cancer ...
ORGANISM(S): Mus musculus 
2020-06-12 | E-MTAB-9163 | biostudies-arrayexpress
ProteomicsPalmdelphin confers nuclear resilience to the aortic valve endothelium
Background: Palmdelphin (PALMD), a protein of unknown function, belongs to the family of Paralemmin proteins implicated in cytoskeletal regulation. Single nucleotide polymorphisms (SNPs) in the PALMD locus, which reduce its expression, are strong risk factors for development of calcific aortic valve...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024887 | Pride
Calcific aortic valve stenosis Rangap1 Actin cap Nucleocytoplasmic transport Endothelial Palmdelphin 
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