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ProteomicsPalmdelphin confers nuclear resilience to the aortic valve endothelium
Background: Palmdelphin (PALMD), a protein of unknown function, belongs to the family of Paralemmin proteins implicated in cytoskeletal regulation. Single nucleotide polymorphisms (SNPs) in the PALMD locus, which reduce its expression, are strong risk factors for development of calcific aortic valve...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024887 | Pride
Calcific aortic valve stenosis Rangap1 Actin cap Nucleocytoplasmic transport Endothelial Palmdelphin 
UnknownPalmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage.
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S-EPMC4047856 | biostudies-literature
UnknownPalmdelphin promotes myoblast differentiation and muscle regeneration.
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S-EPMC5288731 | biostudies-literature
UnknownPalmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium.
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S-EPMC8589083 | biostudies-literature
UnknownIn vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury.
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S-EPMC11579379 | biostudies-literature
UnknownPalmdelphin Deficiency Evokes NF-κB Signaling in Valvular Endothelial Cells and Aggravates Aortic Valvular Remodeling.
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S-EPMC10714178 | biostudies-literature
UnknownEvolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions.
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S-EPMC3405040 | biostudies-literature
UnknownA transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis.
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S-EPMC5840407 | biostudies-literature
UnknownPhenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis.
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S-EPMC7455695 | biostudies-literature
UnknownEnhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis.
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S-EPMC7970363 | biostudies-literature
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