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ProteomicsFactor H and related proteins in AMD
Age-related macular degeneration (AMD) is a common form of adult blindness. Risk of developing AMD is strongly linked to genetics, in particular at the Regulators of Complement Activation (RCA) locus on Chr1, which contains 6 genes, Complement Factor H (CFH) and Complement Factor H-related 1-5 (CFHR...
ORGANISM(S): Homo Sapiens 
2022-01-18 | PXD023466 | panorama
TranscriptomicsTranscript profiling reveals expression differences in wild-type and glabrous soybean lines
Two high throughput transcript sequencing methods, Digital Gene Expression (DGE) Tag Profiling and RNA-Seq, were used to compare the transcriptional profiles in wild-type (cv. Clark standard, CS) and a mutant (cv. Clark glabrous, i.e., trichomeless or hairless, CG) soybean isoline that carries the d...
ORGANISM(S): Glycine max 
2011-10-25 | E-GEOD-33155 | biostudies-arrayexpress
ProteomicsIdentification of novel blood-borne soluble binding partners of factor H-related proteins
The deposition of circulating complement factor H-related (FHR) proteins in tissues around the body has been implicated in a series of complement-mediated diseases. However, the array of blood-borne binding partners with which they interact remains unclear. Here, we identify novel blood-borne bindin...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD072296 | Pride
Fhr Affinity proteomics Blood 
TranscriptomicsMicroarray analysis of RNA stability in mouse Neuro-2A cells
Cells were grown to ~50% confluency before RNA polymerase activity was blocked with 10 µg/mL Actinomycin D (Sigma) in DMSO. Control cells were treated with DMSO alone. Transcriptional inhibition of N2A cells was conducted for 32 h with cells harvested at time zero (0 h) and after 30 min, 2, 4, 8, 16...
ORGANISM(S): Mus musculus 
2012-01-24 | E-MTAB-961 | biostudies-arrayexpress
TranscriptomicsA human transcriptome array for high-throughput clinical studies (with a comparison to RNA-seq technology) [RNA-Seq]
A new high-density oligonucleotide array of the human transcriptome (GG-H array) has been developed for high-throughput and cost-effective analyses in clinical studies. This array allows comprehensive examination of gene expression and genome-wide identification of alternative splicing, as well as ...
ORGANISM(S): Homo sapiens 
2011-01-27 | E-GEOD-26109 | biostudies-arrayexpress
Unknown1H, 13C, and 15N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCH.
Not available
S-EPMC6439258 | biostudies-literature
UnknownBeyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations.
Not available
S-EPMC8387294 | biostudies-literature
UnknownLong-term optical brain imaging in live adult fruit flies.
Not available
S-EPMC5830414 | biostudies-literature
UnknownAn Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity.
Not available
S-EPMC7343168 | biostudies-literature
TranscriptomicsIdentification of pathogenic microRNAs in Helicobacter pylori-associated gastric cancer
To identify dysregulated miRNA(s) upon infection with H. pylori during different pre-malignant and malignant stages of gastric cancer in a mouse model miRNA expression in pre-neoplastic and neoplastic lesions in murine stomachs induced by H. pylori and N-methyl-N-nitrosourea (MNU) after 12 months wa...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-62503 | biostudies-arrayexpress
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