Sort   by:  
 Page size 
TranscriptomicsThe Sm protein methyltransferase PRMT5, is not required for primordial germ cell specification in mice
PRMT5 is a type II protein arginine methyltransferase with roles in stem cell biology, reprogramming, cancer and neurogenesis. During embryogenesis in the mouse it was hypothesized that PRMT5 functions with the master germline determinant BLIMP1 to promote primordial germ cell (PGC) specification. U...
ORGANISM(S): Mus musculus 
2014-12-05 | E-GEOD-63800 | biostudies-arrayexpress
TranscriptomicsMicroenvironment-driven resistance to B-Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts. Genome methylation study.
In this study, we compared gene expression and genome methylation of diverse fibroblast populations from a patient suffering from acrolentiginous melanoma (Breslow 4.0 mm, Clark IV, B-Raf V600E mutated). Stromal cells from the metastasis, i.e., melanoma associated fibroblasts (MAF), were positive fo...
ORGANISM(S): Homo sapiens 
2018-12-30 | E-MTAB-4965 | biostudies-arrayexpress
GenomicsGenome-wide cooperation by HAT Gcn5, remodeler SWI/SNF, and chaperone Ydj1 in promoter nucleosome eviction and transcriptional activation
Chaperones, nucleosome remodeling complexes and histone acetyltransferases have been implicated in nucleosome disassembly at promoters of particular yeast genes, but whether these co-factors function ubiquitously, and the impact of nucleosome eviction on transcription genome-wide, are poorly underst...
ORGANISM(S): Saccharomyces cerevisiae 
2015-11-09 | E-GEOD-74787 | biostudies-arrayexpress
UnknownUsing incidental mark-encounter data to improve survival estimation.
Not available
S-EPMC6972812 | biostudies-literature
TranscriptomicsMicroenvironment-driven resistance to B-Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts. Transcriptomic study.
In this study, we compared gene expression and genome methylation of diverse fibroblast populations from a patient suffering from acrolentiginous melanoma (Breslow 4.0 mm, Clark IV, B-Raf V600E mutated). Stromal cells from the metastasis, i.e., melanoma associated fibroblasts (MAF), were positive fo...
ORGANISM(S): Homo sapiens 
2018-12-31 | E-MTAB-4964 | biostudies-arrayexpress
UnknownRandomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed.
Not available
S-EPMC5089161 | biostudies-literature
GenomicsGenome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation
Fertilization triggers a global erasure of 5-methylcytosine from paternal DNA as part of extensive epigenetic reprogramming during the transition from gametic specialization to totipotency. This active removal has been shown to involve oxidation by TET3, but the targeting of this pathway and the wid...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-63417 | biostudies-arrayexpress
UnknownPathways between childhood/adolescent adversity, adolescent socioeconomic status, and long-term cardiovascular disease risk in young adulthood.
Not available
S-EPMC5558845 | biostudies-literature
UnknownIncrease of perceived frequency of neighborhood domestic violence is associated with increase of women's depression symptoms in a nationally representative longitudinal study in South Africa.
Not available
S-EPMC4382311 | biostudies-literature
UnknownRelationship between bacterial phylotype and specialized metabolite production in the culturable microbiome of two freshwater sponges
Not available
S-EPMC9723699 | biostudies-literature
Sort   by:  
 Page size