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TranscriptomicsThe impact of P53 loss on transcriptome changes following loss of Apc in the intestine
BACKGROUND: p53 is an important tumor suppressor with a known role in the later stages of colorectal cancer, but its relevance to the early stages of neoplastic initiation remains somewhat unclear. Although p53-dependent regulation of Wnt signalling activity is known to occur, the importance of thes...
ORGANISM(S): Mus musculus 
2015-06-25 | E-GEOD-70262 | biostudies-arrayexpress
TranscriptomicsB-catenin deficiency, but not c-Myc deletion, suppresses the immediate phenotypes of Apc loss in the liver
Dysregulated Wnt signalling is seen in approximately 30% of hepatocellular cancers, thus finding pathways downstream of activation of Wnt signalling is key. Using cre lox technology we have deleted the the adenomatous polyposis coli tumour suppressor protein (Apc) within the adult mouse liver and ob...
ORGANISM(S): Mus musculus 
2015-01-31 | E-GEOD-65476 | biostudies-arrayexpress
UnknownThe nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.
Not available
S-EPMC5018401 | biostudies-literature
GenomicsMus musculus
Transcriptome analysis of Brg1 deficient small intestinal epithelium in the context of normal and aberrant Wnt signalling
PRJNA197327 | ENA
TranscriptomicsTranscriptome changes following loss of Apc in the intestine
Nearly all colorectal cancers have dysregulated Wnt signalling, predominantly through the mutation of the Apc (Adenomatous Polyposis Coli) gene. Therefore it is of vital importance to elucidate the key Wnt target genes in intestinal cells in vivo. We have used a novel inducible cre-lox based murine ...
ORGANISM(S): Mus musculus 
2015-01-31 | E-GEOD-65461 | biostudies-arrayexpress
TranscriptomicsProfiling of SF188 ATRX isogenic glioma cells
Methylation profiling of SF188 paediatric high grade glioma cell line isogenic clones carrying CRISR/Cas9 frameshift deletions in ATRX
ORGANISM(S): Homo sapiens 
2019-06-01 | E-MTAB-7800 | biostudies-arrayexpress
TranscriptomicsIllumina Infinium HumanMethylation 450k Profiling of paediatric diffuse type high grade gliomas and patient derived xenografts
Methylation array based profiling of paediatric diffuse type high grade glioma primary tumours and patient derived orthotropic xenografts (PDX) in mice.
ORGANISM(S): Homo sapiens 
2026-03-31 | E-MTAB-16763 | biostudies-arrayexpress
TranscriptomicsIllumina Infinium HumanMethylation EPIC Profiling of paediatric diffuse type high grade gliomas and patient derived xenografts
Methylation array based profiling of paediatric diffuse type high grade glioma primary tumours and patient derived orthotropic xenografts (PDX) in mice.
ORGANISM(S): Homo sapiens 
2026-03-31 | E-MTAB-16762 | biostudies-arrayexpress
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-12 | E-MTAB-7804 | biostudies-arrayexpress
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-09 | E-MTAB-7802 | biostudies-arrayexpress
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