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ProteomicsComprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes
Monocytes are a critical component of the cellular innate immune system, and can be subdivided into classical, intermediate and non-classical subsets on the basis of surface CD14 and CD16 expression. Classical monocytes play the canonical role of phagocytosis, and account for the majority of circula...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD013832 | Pride
Classical monocyte Monocyte Blood cell Cell surface Quantitative proteomics Tandem mass tag Plasma membrane 
TranscriptomicsSuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset
Monocytes are a heterogeneous cell population with subset-specific functions and phenotypes. The differential expression of CD14 and CD16 distinguishes classical CD14++CD16-, intermediate CD14++CD16+ and non-classical CD14+CD16++ monocytes. However, CD14++CD16+ monocytes remain the most poorly chara...
ORGANISM(S): Homo sapiens 
2011-07-24 | E-GEOD-30811 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of the classical (CD14++CD16-), intermediate (CD14++CD16+) and nonclassical (CD14+CD16+) human monocyte subsets
The new official nomenclature subdivides human monocytes into three subsets, classical (CD14++CD16-), intermediate (CD14++CD16+) and nonclassical (CD14+CD16+). Here, we comprehensively define relationships and unique characteristics of the three human monocyte subsets using microarray and flow cytom...
ORGANISM(S): Homo sapiens 
2011-05-01 | E-GEOD-25913 | biostudies-arrayexpress
TranscriptomicsMonocyte Transmigration
We investigated the hypothesis that transmigration drives monocyte transcriptional changes. Using Agilent Whole Human Genome Microarrays, we identified over 600 differentially expressed genes (2x, p<0.05) in freshly isolated human monocytes following 1.5 h of transmigration across IL1beta-stimulate...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-14027 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of human blood monocyte subsets highlights functional differences
Identification of micro-RNAs involved in regulating differential apoptosis and migration potential of human monocyte subsets Comparision between freshly isolated CD14++CD16- monocytes and CD14+CD16+ monocytes from healthy human blood
ORGANISM(S): Homo sapiens 
2015-03-07 | E-GEOD-52986 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of activated mixed glial (microglia) and monocyte-derived macrophages
Since macrophage activation can now be studied at a global level using modern microarray and proteomic analyses, discovery of novel macrophage activation genes is inevitable and important for understanding HIV-associated dementia (HAD). We isolated two different types of primary human macrophages, m...
ORGANISM(S): Homo sapiens 
2007-08-29 | E-GEOD-1910 | biostudies-arrayexpress
TranscriptomicsChronic psoriatic skin inflammation leads to increased monocyte adhesion and aggregation
Psoriasis patients exhibit an increased risk of death by cardiovascular disease (CVD) and have elevated levels of circulating intermediate (CD14++CD16+) monocytes. This elevation could represent evidence of monocyte dysfunction in psoriasis patients at risk of CVD, as increases in circulating CD14++...
ORGANISM(S): Homo sapiens 
2015-06-27 | E-GEOD-70327 | biostudies-arrayexpress
GenomicsRNA-Seq analysis of classical monocyte in pateints with sickle cell disease [RNA-Seq]
RNA-Seq analysis of classical monocyte in pateints with sickle cell disease [RNA-Seq]
PRJNA708217 | ENA
TranscriptomicsTranscription profiling of human monocyte-derived macrophages infected in vitro with wild type Leishmania chagasi parasites and then cultured with naive, autologous T-cells
We performed gene expression analysis using Affymetrix U133Plus2 microarray chips on cultures of infected human cells. To mimic an in vivo infection, we infected human monocyte-derived macrophages (MDMs) in vitro with wild-type L. chagasi parasites and then co-cultured those infected MDMs with naiv...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-MEXP-1290 | biostudies-arrayexpress
GenomicsGranulocyte Derived Resistin Induces Classical Monocyte Repartition and Immune Suppression in CMML
Granulocyte Derived Resistin Induces Classical Monocyte Repartition and Immune Suppression in CMML
PRJNA1261053 | ENA
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