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ProteomicsComprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes
Monocytes are a critical component of the cellular innate immune system, and can be subdivided into classical, intermediate and non-classical subsets on the basis of surface CD14 and CD16 expression. Classical monocytes play the canonical role of phagocytosis, and account for the majority of circula...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD013832 | Pride
Classical monocyte Monocyte Blood cell Cell surface Quantitative proteomics Tandem mass tag Plasma membrane 
TranscriptomicsTranscriptomic Signatures of Classical Monocytes Reveal Pro-Inflammatory Modules and Heterogeneity in Polyarticular Juvenile Idiopathic Arthritis
Polyarticular Juvenile Idiopathic Arthritis (pJIA) is a childhood-onset autoimmune disease. Immune cells contribute to persistent inflammation observed in pJIA. Despite the crucial roleof monocytes in arthritis, the precise involvement of classical monocytes in the pathogenesis of pJIA remains uncer...
ORGANISM(S): Homo sapiens 
2024-05-06 | E-MTAB-14035 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of lung monocytes and macrophages in mice
We developed a simplified flow cytometry strategy in order to discriminate monocytes and macrophages in the lung of C57BL/6 mice. Using this strategy, we identified autofluorescent F4/80+ CD11c+ alveolar macrophages, non-autofluorescent CD64+Ly-6C- interstitial macrophages and Ly-6Chi monocytes resi...
ORGANISM(S): Mus musculus 
2017-03-01 | E-MTAB-5012 | biostudies-arrayexpress
ProteomicsTranscriptomic and proteomic profiling of non-classical monocytes unravels distinct pathogenic features in SLE
Current non-specific immunosuppressive treatments for Systemic Lupus Erythematosus (SLE) show modest efficacy. In SLE the monocytic/macrophage (Mo/Mφ) system plays a key role in the initiation and perpetuation of the systemic autoimmune response. However, the distinct functions of the Mo/Mφ cellular...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD042539 | Pride
Proteomics Non-classical monocytes Differentiation Cytokines M1 macrophages Autoimmunity Cell cycle Transcriptomics Systemic lupus erythematosus 
TranscriptomicsTranscriptomic characterization of classical monocytes highlights the involvement of immuno-inflammation in bone erosion in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with localized bone involvement characterized by the presence of bone erosions. Evidence-based data suggest that under inflammatory conditions, classical monocytes are the main source of osteoclasts and might be involved in bone ...
ORGANISM(S): Homo sapiens 
2023-09-19 | E-MTAB-13361 | biostudies-arrayexpress
GenomicsTranscriptomic analysis of SLAN+ vs SLAN- non-classical monocytes
Transcriptomic analysis of SLAN+ vs SLAN- non-classical monocytes
PRJNA503867 | ENA
GenomicsDonor non-classical monocytes recruit recipient classical monocytes from the spleen by activating donor alveolar macrophages
Donor non-classical monocytes recruit recipient classical monocytes from the spleen by activating donor alveolar macrophages
PRJNA701602 | ENA
TranscriptomicsSuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset
Monocytes are a heterogeneous cell population with subset-specific functions and phenotypes. The differential expression of CD14 and CD16 distinguishes classical CD14++CD16-, intermediate CD14++CD16+ and non-classical CD14+CD16++ monocytes. However, CD14++CD16+ monocytes remain the most poorly chara...
ORGANISM(S): Homo sapiens 
2011-07-24 | E-GEOD-30811 | biostudies-arrayexpress
GenomicsAnalysis of human classical and non-classical monocytes compared to their dendritic cell counterpart.
Analysis of human classical and non-classical monocytes compared to their dendritic cell counterpart.
PRJNA418159 | ENA
GenomicsTranscriptome profiling of classical monocytes in ME/CFS post exercise challenge
Transcriptome profiling of classical monocytes in ME/CFS post exercise challenge
PRJNA884705 | ENA
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