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MetabolomicsRich organic nitrogen impacts clavulanic acid biosynthesis through the arginine metabolic pathway in Streptomyces clavuligerus F613-1

Clavulanic acid (CA) is the preferred clinical drug for the treatment of infections by β-lactam antibiotic-resistant bacteria. CA is produced by Streptomyces clavuligerus, and although there have been many reports on the effects of carbon and nitrogen sources on CA production, the mechan...

2022-12-08 | MTBLS5744 | MetaboLights
ProteomicsAn integrative transcriptomic and proteomic analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus
Clavulanic acid is a clinically-important secondary metabolite used in treatment of infectious diseases. We aimed to decipher complex regulatory mechanisms acting in clavulanic acid biosynthesis through the analysis of transcriptome- and proteome-wide alterations in an industrial clavulanic acid ove...
ORGANISM(S): Streptomyces clavuligerus 
2022-11-02 | PXD032272 | Pride
Streptomyces clavuligerus depa Rna seq Nanolc-ms/ms Clavulanic acid overproduction 
ProteomicsBiotin-Labelled Clavulanic Acid to Identify Proteins Target for Haptenation in Serum
Clavulanic acid (CLV) is a betalactam (BL) which inhibits betalactamases activity and is frequently administered combined with amoxicillin (AX). Both BLs can be independently involved in allergic reactions. Indeed, selective immediate allergic reactions to CLV have recently been reported in 30% of p...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021675 | Pride
Clavulanate Blot and biotin detection Clavulanic acid Biotinylation Biotin tag Haptenation 
MetabolomicsGNPS Metabolomics and Genomics Analysis of Clavulanic Acid Producing Streptomyces Species
Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters. Run a Scherzo column. Positive and negative ionisation mode. The first deposition contains RAW, mzM...
ORGANISM(S): Streptomyces Jumonjinensis (ncbitaxon:1945) Streptomyces Clavuligerus (ncbitaxon:1901) Streptomyces Katsurahamenas (ncbitaxon:329527) 
2019-05-21 | MSV000083835 | GNPS
GenomicsRS07910/07915 TCS multipath regulates clavulanic acid metabolic pathways in Streptomyces clavuligerus F613-1
RS07910/07915 TCS multipath regulates clavulanic acid metabolic pathways in Streptomyces clavuligerus F613-1
PRJNA488466 | ENA
TranscriptomicsEffect of organic nitrogen on gene expression of clavulanic acid biosynthesis in Streptomyces clavuligerus F613-1
To investigate the function of organic nitrogen on clavulanic acid biosynthesis in Streptomyces clavuligerus, we established F613-1 strain cells cultured in MH fermentation medium and ML fermentation medium. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 d...
ORGANISM(S): Streptomyces clavuligerus 
2022-08-25 | GSE211765 | GEO
TranscriptomicsRS07910/07915 TCS multipath regulates clavulanic acid metabolic pathways in Streptomyces clavuligerus F613-1
Streptomyces clavuligerus F613-1 produces a clinically important β-lactamase inhibitor, clavulanic acid (CA). The biosynthesis pathway of CA has been basically elucidated, however, the global regulation of CA biosynthesis remains unclear. In order to further elucidate the regulatory mechanism of cla...
ORGANISM(S): Streptomyces clavuligerus 
2018-08-30 | GSE119208 | GEO
GenomicsEffect of organic nitrogen on gene expression of clavulanic acid biosynthesis in Streptomyces clavuligerus F613-1
Effect of organic nitrogen on gene expression of clavulanic acid biosynthesis in Streptomyces clavuligerus F613-1
PRJNA872036 | ENA
GenomicsStreptomyces jumonjinensis and Streptomyces katsurahamanus
Clavulanic acid producing Streptomyces species Genome sequencing
PRJNA542368 | ENA
UnknownFive additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.
Not available
S-EPMC310172 | biostudies-literature
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