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MetabolomicsCholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria
Efficient clearance and recycling of dysfunctional mitochondria through the robust catabolic activity of lysosomes is essential for cellular health. However, how membrane lipids contribute to maintaining the degradative capacity of lysosomes remains poorly understood. Here, we show that cholesterol ...
2026-07-30 | MTBLS15181 | MetaboLights
MetabolomicsVesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer

Selective autophagy of mitochondria is known to promote survival and progression of cancer cells in various malignancies, including triple-negative breast cancer (TNBC). Here, we investigate the essential metabolic adaptations that support mitochondrial quality control in cancer cells with the ai...

2025-09-30 | MTBLS13037 | MetaboLights
MetabolomicsComprehensive biotransformation analysis of phenylalanine-tyrosine metabolism reveals alternative routes of metabolite clearance in nitisinone-treated alkaptonuria (Urine metabolomic analysis)
Not available
ORGANISM(S): Homo sapiens 
ST002297 | MetabolomicsWorkbench
MetabolomicsComprehensive biotransformation analysis of phenylalanine-tyrosine metabolism reveals alternative routes of metabolite clearance in nitisinone-treated alkaptonuria (Serum metabolomic analysis)
Not available
ORGANISM(S): Homo sapiens 
ST002296 | MetabolomicsWorkbench
ModelsQosa2014 - Mechanistic modeling that describes amyloid-Beta clearance across BBB
Qosa2014 - Mechanistic modeling that describes Aβ clearance across BBB Qosa2014 - Mechanistic modeling that describes Aβ clearance across BBB. Encoded non-curated model. Issues: - Confusing equation 6 - Missing initial values for spices This model is described in the article: Dif...
2015-04-15 | MODEL1409240002 | BioModels
GenomicsMethotrexate Clearance GWAS in Acute Lymphoblastic Leukemia (ALL) Patients

We estimated the plasma clearance of methotrexate from 1279 acute lymphoblastic leukemia (ALL) patients treated on the Children Oncology Group 9904 and 9905 trials (http://clinicaltrials.gov/show/NCT00005585 and

phs000637.v1.p1 | EGA
ProteomicsDevelopmental mRNA clearance by PIWI-bound endo-siRNAs in Paramecium
The clearance of untranslated mRNAs by Argonaute proteins is essential for embryonic development in metazoans. However, it is currently unknown whether a similar process exists in unicellular eukaryotes. The ciliate Paramecium tetraurelia harbors a vast array of Argonaute proteins of the Piwi-clade ...
ORGANISM(S): Paramecium tetraurelia 
2023-05-10 | PXD038984 | Pride
Paramecium tetraurelia Piwi Mrna clearance Untranslated mrna Total protein < 25kda Sirnas 
TranscriptomicsType I IFN-signaling following Pneumocystis (PC)-infection and clearance in CD4 T cell-competent mice
Type I IFN-signaling suppresses an excessive IFN-{gamma} response and prevents lung damage and chronic inflammation following Pneumocystis (PC)-infection and clearance in CD4 T cell-competent mice. Type I IFN -signaling in pulmonary CD11c+ DCs and alveolar macrophages may prevent chronic inflammatio...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-18607 | biostudies-arrayexpress
TranscriptomicsBlood transcriptomes of chronic HCV patients four years after therapy-induced viral clearance
Little is known on the immune status in liver and blood of chronic HCV patients long after therapy-induced viral clearance. In this study, we demonstrate that 4 years after clearance, regulation of HCV-specific immunity in blood by regulatory T-cells (Treg) and the immunosuppressive cytokines IL-10 ...
ORGANISM(S): Homo sapiens 
2015-04-06 | E-GEOD-64603 | biostudies-arrayexpress
TranscriptomicsA novel insulin receptor-binding protein enhances glucose uptake and glucose clearance in vitro and in vivo through triggering insulin receptor signaling pathway
In this study, a novel IR-binding protein (IRBP) from Momordica charantia, named as mcIRBP, was identified by analyzing the physical and functional interactions between mcIRBP and IR. The hypoglycemic effect and mechanism of mcIRBP were further evaluated in normal and streptozotocin-induced diabetic...
ORGANISM(S): Mus musculus 
2016-06-25 | E-GEOD-48274 | biostudies-arrayexpress
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