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ProteomicsImproved peptide backbone fragmentation is the primary advantage of MS-cleavable crosslinkers
Proteome-wide crosslinking mass spectrometry studies have coincided with the advent of MS-cleavable crosslinkers that can reveal the individual masses of the two crosslinked peptides. However, recently such studies have also been published with non-cleavable crosslinkers suggesting that MS-cleavabil...
ORGANISM(S): Mus musculus (Mouse) Escherichia coli Drosophila melanogaster (Fruit fly) 
2022-06-24 | PXD032821 | Pride
Lc-msms Dsbu Ms-cleavable crosslinker Dsso Crosslinking Clms 
ProteomicsFixated rat liver tissue - Cleavable crosslinkers as tissue fixation reagents for proteomic analysis
Formaldehyde fixation is widely used for long-term maintenance of tissue. However, due to formaldehyde-induced cross-links, fixated tissue proteins are difficult to extract hampering the performance of mass spectrometry (MS)-proteomic analysis on formaldehyde-fixated tissue. Recent years saw the use...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-01-29 | PXD002169 | Pride
Rat liver Tissue fixation Cleavable crosslinkers Reversible crosslinking 
UnknownImproved Peptide Backbone Fragmentation Is the Primary Advantage of MS-Cleavable Crosslinkers.
Not available
S-EPMC9178559 | biostudies-literature
UnknownAn enhanced protein crosslink identification strategy using CID-cleavable chemical crosslinkers and LC/MS(n) analysis.
Not available
S-EPMC3426502 | biostudies-literature
ProteomicsCleavable Photo-Crosslinker Enables sFFP-Driven Strategy for Mapping HSP90β Oligomer Structure
Crosslinking technology is a pivotal tool for resolving dynamic protein interaction networks. While traditional chemical crosslinkers face limitations in sensitivity, reaction kinetics, and in situ activation, cleavable and photo-crosslinkers have emerged as alternatives. However, their complex spec...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2026-04-09 | PXD064219 | Pride
Photo-cross-link Hsp90 Randomforest Cleavable cross-linker 
UnknownEngineered extracellular matrices with cleavable crosslinkers for cell expansion and easy cell recovery.
Not available
S-EPMC2651085 | biostudies-literature
UnknownExpanding the Crosslinking Mass Spectrometry Toolbox With Vinyl Sulfone Crosslinkers.
Not available
S-EPMC12682122 | biostudies-literature
UnknownIncreased sensitivity with automated validation of XL-MS cleavable peptide crosslinks.
Not available
S-EPMC6394394 | biostudies-literature
ProteomicsExpanding the crosslinking mass spectrometry toolbox with vinyl sulfone crosslinkers
Crosslinking mass spectrometry (MS) is a powerful approach for probing protein structures. However, most widely used crosslinkers rely on N-hydroxysuccinimide (NHS) esters, restricting reactivity primarily to lysine residues and protein N-termini, and rendering them incompatible with many amine-cont...
ORGANISM(S): Homo sapiens (Human) 
2025-11-29 | PXD065869 | Pride
Mass spectrometry Vinyl sulfone Crosslinking 
ProteomicsExpanding the crosslinking mass spectrometry toolbox with vinyl sulfone crosslinkers
Crosslinking mass spectrometry (MS) is a powerful approach for probing protein structures. However, most widely used crosslinkers rely on N-hydroxysuccinimide (NHS) esters, restricting reactivity primarily to lysine residues and protein N-termini, and rendering them incompatible with many amine-cont...
ORGANISM(S): Homo sapiens (Human) 
2025-11-29 | PXD065858 | Pride
Mass spectrometry Vinyl sulfone Crosslinking 
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