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MetabolomicsThe microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the gut
Gut microbiomes play a key role in the maintenance of host metabolic homeostasis and health. An important aspect of metabolism is its circadian regulation, but how the microbiome regulates metabolite cycling under different conditions, including variations in dietary composition, remains undefined. ...
2025-04-08 | MTBLS8819 | MetaboLights
ProteomicsInteractome of the circadian clock protein PERIOD2 in human U2OS osteosarcoma cells after the resetting of the circadian clock
Circadian rhythms are a series of endogenous autonomous 24-hour oscillations generated by the circadian clock. At the molecular level, the circadian clock is generated by a transcription-translation feedback loop, where BMAL1 and CLOCK transcription factors of the positive arm activate the expressio...
ORGANISM(S): Homo sapiens (Human) 
2022-04-22 | PXD025179 | Pride
Protein−protein interactions Proteomics Period2 Circadian clock Bioid 
TranscriptomicsCircadian liver_wt and Clock mutants
One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into ...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-3748 | biostudies-arrayexpress
TranscriptomicsCircadian rhythm in clock mutants
One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into ...
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-3751 | biostudies-arrayexpress
TranscriptomicsCircadian skeletal muscle_wt and Clock mutants
One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into ...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-3746 | biostudies-arrayexpress
TranscriptomicsSKIP Is a Component of the Spliceosome Linking Alternative Splicing and the Circadian Clock in Arabidopsis
Circadian clocks generate endogenous rhythms in most organisms from cyanobacteria to humans and facilitate entrainment to environmental diurnal cycles, thus conferring a fitness advantage. Both transcriptional and posttranslational mechanisms are prominent in the basic network architecture of circad...
ORGANISM(S): Arabidopsis thaliana 
2012-12-13 | E-GEOD-32216 | biostudies-arrayexpress
ProteomicsDirect evaluation of metabolic rhythms from quantitative circadian proteomics revealed rampant post-transcriptional regulation by Chlamydomonas clock
Temporal dynamics in an organism's behavior, physiology, metabolism, and biochemistry over the course of 24 hours are governed by an inherent cellular clock. Transcriptomic studies revealed that the clock is governed by intricate transcriptional and translational feedback loops(TTFLs) involving dail...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-05-27 | PXD043839 | Pride
Post-transcriptional regulations Swath-ms Proteomics C. reinhardtii Circadian clock 
Transcriptomicscircadian clock in cartilage
This experiment investigated the circadian clock in mice cartilage. A microarray time-series was performed using xiphoid tissue (metasternum) from mice in constant darkness. Time points were every 4 hr for 40 hr in total.
ORGANISM(S): Mus musculus 
2013-10-19 | E-MEXP-3780 | biostudies-arrayexpress
ProteomicsCircadian clock control of ribosome composition promotes rhythmic translation and termination fidelity
We describe circadian clock-dependent changes in ribosome composition in Neurospora crassa depending on cell type, stress, or developmental state. Mass spectrometry of ribosomes isolated at different circadian times identified six ribosomal proteins and one ribosome-associated protein with clock-con...
ORGANISM(S): Neurospora Crassa (ncbitaxon:5141) 
2024-10-15 | MSV000096101 | MassIVE
TranscriptomicsTranscription profiling of livers from wild type, Clock mutant and Cry deficient C57BL/6 mice to characterize CLOCK-regulated circadian output genes.
Molecular analysis of circadian rhythm in mice. Liver tissue of wildtype, Clock mutant and Cry deficient C57BL/6 8- to 10-week-old male mice examined.
ORGANISM(S): Mus musculus 
2007-11-07 | E-GEOD-454 | biostudies-arrayexpress
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