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MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
TranscriptomicsGenomic diversity of a pneumococcal clonal complex, 199
Comparative genomic hybridisation of Streptococcus pneumoniae isolates from a single clonal complex, in order to determine genomic diversity. Isolates were selected from a range of tissue types and serotypes in order to cover the full diversity of the clone, and also in order to try and identify tis...
ORGANISM(S): Streptococcus pneumoniae 
2010-09-07 | E-GEOD-23992 | biostudies-arrayexpress
ProteomicsShotgun and geLC MS/MS data of clonal enrichment culture BzS1
Due to its high chemical stability, the biodegradation of benzene is the most challenging amongst hydrocarbons. While oxygen-dependent oxygenases are employed by aerobic bacteria to overcome the energy barrier, the mechanism of anaerobic benzene biodegradation is still enigmatic. The sulfate-reducin...
ORGANISM(S): bacterium BzS1 
2026-09-07 | PXD080844 | Pride
Anaerobic benzene degradation Lc-msms Shotgun and gelc ms/ms data of clonal enrichment culture bzs1 keywords strain bzs1 
GenomicsST-677 clonal complex evolution
Campylobacter jejuni ST-677 clonal complex evolution and comparative genomics (5070)
PRJEB5964 | ENA
GenomicsCampylobacter jejuni ST-677 clonal complex
Campylobacter jejuni ST-677 clonal complex evolution and comparative genomics
PRJEB5977 | ENA
MetabolomicsCell of origin epigenetic priming determines susceptibility to Tet2 mutation

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights
TranscriptomicsPotential Influence of Staphylococcus aureus Clonal Complex 30 Genotype and Transcriptome on Hematogenous Infections
We report the application of RNA-Seq to assess genomic transcriptional profiles of S. aureus clinical isolates from Clonal Complex 30 and related genetic backgrounds. In this study, CC30 isolates were shown to be significantly less virulent than other CCs in two in vivo sepsis models. The associatio...
ORGANISM(S): Staphylococcus aureus 
2014-07-29 | E-GEOD-59851 | biostudies-arrayexpress
TranscriptomicsClonal evolution and devolution following chemotherapy in adult acute myelogenous leukemia
The frequent occurrence of persistent or relapsed disease following induction chemotherapy in AML necessitates a better understanding of the clonal relationship of AML in various disease phases. In this study, we employed SNP 6.0 array-based genomic profiling of acquired copy number aberrations (aCN...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-41646 | biostudies-arrayexpress
ProteomicsPhosphoproteomics measurement of clonal endocrine therapy sensitive and resistant breast cancer populations
Around two thirds of breast tumors are characterized by the expression of estrogen receptor α and are therapeutically treated by blocking estrogen signaling. First line endocrine therapeutics are Tamoxifen which displaces estrogen form its receptor preventing receptor activation and aromatase inhibi...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040478 | Pride
Phosphoproteomics Clonal deconvolution Breast cancer Therapy resistance 
ProteomicsDirect comparison of the hinge-cleaving proteases IgdE and BdpK for LC-MS based IgG1 clonal profiling
Human antibodies are heterogeneous molecules, primarily due to clonal sequence variations. Analytical techniques to assess antibody levels quantitatively, like ELISA assays, lack the power to determine abundances at the clonal level. Recently, we introduced an LC-MS-based approach that can distingui...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-17 | MSV000092676 | MassIVE
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