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TranscriptomicsTranscription profiling of human neuroblastoma cell line SHEP expressing a MYNC trasngene against controls which have the transgene silenced by tetracycline
MYCN is an oncogene amplified in approximately 20% of all neuroblastomas and 50% of high risk neuroblastoma. It is a transcription factor regulating the expression of genes involved in proliferation and apoptosis.We would like to identify genes potentially regulated by MYCN in a conditional MYCN exp...
ORGANISM(S): Homo sapiens 
2010-02-18 | E-MEXP-2340 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Acanthamoeba polyphaga mimivirus infecting Acanthamoeba castellanii for different lengths of time
A culture of Acanthamoeba castellanii cells was infected with mimivirus. At specified times after infection, infected cells aliquots were subjected to total RNA extraction. Cy3 labeled cDNA was hybridized on custom designed Agilent oligonucleotide tiling microarrays covering both strands of the mimi...
ORGANISM(S): Acanthamoeba polyphaga mimivirus 
2010-03-18 | E-MTAB-187 | biostudies-arrayexpress
TranscriptomicsStem cell factor programs the mast cell activation phenotype
Mast cells, activated by antigen via the high affinity receptor for IgE (FcεRI), release an array of pro-inflammatory mediators that contribute to allergic disorders such as asthma and anaphylaxis. The KIT ligand, stem cell factor (SCF), is critical for mast cell expansion, differentiation and survi...
ORGANISM(S): Mus musculus 
2012-05-01 | E-GEOD-35332 | biostudies-arrayexpress
TranscriptomicsMicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Danio rerio 
2013-09-16 | E-GEOD-45410 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiles of interstitial lung disease (ILD) patients
The mechanisms and molecular pathways underlying interstitial lung diseases (ILDs) are poorly understood. Systems biology approaches were used to identify perturbed networks in these disease states to gain a better understanding of the underlying mechanisms of disease. Through profiling genes and mi...
ORGANISM(S): Homo sapiens 
2011-04-19 | E-GEOD-21394 | biostudies-arrayexpress
TranscriptomicsTranscriptomic-Based Effects Monitoring for Endocrine Active ChemicalsM-bM-^@M-^TAssessing Relative Contribution of Treated Wastewater to Downstream Pollution
Many biomonitoring tools/approaches have been proposed to assess presence of endocrine active chemicals (EACs) and their biological effects in the field. Although these tools have provided valuable information, they are often limited by their specificity for certain groups of EACs and they may not a...
ORGANISM(S): Pimephales promelas 
2014-01-04 | E-GEOD-49098 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profile of human trabecular meshwork cells induced by triamcinolone with dexamethasone
PURPOSE. Triamcinolone acetonide (TA) and dexamethasone (DEX) are corticosteroids commonly used for ocular inflammation but both can cause ocular hypertension. We investigated the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA compared to ...
ORGANISM(S): Homo sapiens 
2008-05-01 | E-GEOD-6298 | biostudies-arrayexpress
TranscriptomicsGene expression change in cyclin D1 -/- retinas in comparison to wildtype.
Cyclin D1 belongs to the core cell cycle machinery1, and it is frequently overexpressed in human cancers2. The full repertoire of cyclin D1 functions in normal development and in cancer cells is currently unknown. To address this question, here we introduce a novel approach that allows one to deter...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-13635 | biostudies-arrayexpress
TranscriptomicsGenomeTiling
Samples were purchased from Clontech as mRNA. Hybridization material was generated through a random-priming amplification procedure (RP-AMP) using primers with a random sequence at the 3' end and a fixed motif at the 5' end. shDNP256 (first strand synthesis): 5'- TAG ATG CTG TTG NNN NNN NNN -3' sh...
ORGANISM(S): Homo sapiens 
2004-03-03 | E-GEOD-1097 | biostudies-arrayexpress
TranscriptomicsMicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [RNA-seq]
We used zebrafish embryos as an in vivo system to investigate the role of the microRNA-146 family (consisting of 2 members miR-146a and miR-146b) in the innate immune response to S. typhimurium infection. To determine the role of miR-146 microRNAs in the response to S. typhimurium infection we used...
ORGANISM(S): Danio rerio 
2013-09-16 | E-GEOD-45209 | biostudies-arrayexpress
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