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GenomicsThe DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer (ChIP-seq)
This study was aimed at understanding the genome-wide binding and regulatory role of the DAXX transcriptional repressor, recently implicated in PCa. ChIP-Seq analysis of genome-wide distribution of DAXX in PC3 cells revealed over 59,000 DAXX binding sites, found at regulatory enhancers and promoters...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-68647 | biostudies-arrayexpress
TranscriptomicsThe DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer (RNA-seq)
This study was aimed at understanding the genome-wide binding and regulatory role of the DAXX transcriptional repressor, recently implicated in PCa. ChIP-Seq analysis of genome-wide distribution of DAXX in PC3 cells revealed over 59,000 DAXX binding sites, found at regulatory enhancers and promoters...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-68645 | biostudies-arrayexpress
TranscriptomicsLactobacillus johnsonii NCC comparative genomics with L. iatae
Whole genome DNA microarray designed for the probiotic L. johnsonii strain NCC533 was used for comparative genomic hybridization (CGH) of L. johnsonii ATCC 33200T, L. johnsonii BL261, L. gasseri ATCC 33323T and L. iatae BL263 (CECT 7394T). In these experiments, the fluorescence ratio distributions o...
ORGANISM(S): Lactobacillus johnsonii 
2010-11-24 | E-GEOD-21627 | biostudies-arrayexpress
TranscriptomicsTranscriptomic changes induced in yeast cells by the lack of potassium in the medium
Potassium is the major intracellular cation in S. cerevisiae, which can be concentrated up to 200-300 mM even from relatively low potassium (< 1 mM) environments. This is achieved by mean of a high affinity K+-transport system encoded by the genes TRK1 and TRK2. Recently, our group became interested...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-13 | E-GEOD-24712 | biostudies-arrayexpress
TranscriptomicsIdentification of sigB inhibitors in L. monocytogenes
The extensively studied intracellular pathogen, L. monocytogenes, is an ideal model for identifying small-molecule agents for treating bacterial infections. By selecting specific biological targets in L. monocytogenes, which are common to Gram-positive pathogens, we could extrapolate drug discovery ...
ORGANISM(S): Listeria monocytogenes 10403S 
2011-12-06 | E-GEOD-16887 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profile of yeast cells lacking the high affinity K+-transport system
Potassium is the major intracellular cation in S. cerevisiae, which can be concentrated up to 200-300 mM even from relatively low potassium (< 1 mM) environments. This is achieved by mean of a high affinity K+-transport system encoded by the genes TRK1 and TRK2. Recently, our group became interested...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-13 | E-GEOD-24711 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of aortic media from L-NAME and atorvastatin treated male rats
One-month-old male Fischer 344 rats with an initial body weight of 150 g were used for this study and were divided into 7 groups: a control group (30 days), 2 groups intoxicated with L-NAME (50 mg/kg per day in the drinking water; Sigma Chemical Co) for 15 and 30 days, 2 groups treated with atorvast...
ORGANISM(S): Rattus norvegicus 
2006-12-31 | E-MEXP-33 | biostudies-arrayexpress
TranscriptomicsbHLH transcription factors facilitating K+ uptake during stomatal opening are repressed by abscisic acid through phosphorylation
Stomata open in response to light and close following exposure to abscisic acid (ABA). They regulate gas exchange between plants and atmosphere, allowing plants to adapt to changing environmental conditions. ABA binding to receptors initiates a signaling cascade that involves protein phosphorylation...
ORGANISM(S): Arabidopsis thaliana 
2013-06-17 | E-GEOD-46574 | biostudies-arrayexpress
TranscriptomicsComparison of KrasG12D/WT;p53Fx/Fx and KrasG12D/G12D;p53Fx/Fx MEFs
Microarray expression data generated to compare the biological impact of KrasG12D allelic duplication in p53null mouse embryonic fibroblasts (MEFs). The RAS/MAPK-signalling pathway is frequently deregulated in non-small cell lung cancer (NSCLC), often through activating mutations in KRAS. Mouse mode...
ORGANISM(S): Mus musculus 
2016-02-24 | E-GEOD-75871 | biostudies-arrayexpress
UnknownAssessing cellular response to functionalized α-helical peptide hydrogels.
Not available
S-EPMC4276410 | biostudies-literature
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