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ProteomicsMultiomic analysis identifies involvement of complement-dependent pathways in outcomes after repetitive mild closed head injury
Repetitive mild closed head injury (rmCHI) is a common type of traumatic brain injury and its incidence is increasing, not least due to an increase in the number of sports-related injuries. The underlying neuroimmune mechanisms secondary to trauma that link rmCHI to cognitive decline are not well...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-01 | PXD053772 | Pride
Complement system Repetitive Rnaseq Cytof Traumatic brain injury Closed head Proteomics Microglia 
ProteomicsAssessing the effect of number of single hit vs. 3 repetitive hits in a mouse of closed head injury (rCHI) at 3 and 7 days post injury (DPI) in the cortex and hippocampus tissue
Mouse model of closed head injury (rCHI) was assessed for the effect of single hit vs. repetitive hits (3 hits) on the behavioral, biochemical and neuroproteomics changes at the acute (3 days) and sub chronic (7 days) time points in the cortex and hippocampus brain regions. This study will assess th...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-23 | PXD011418 | Pride
Mouse Hippocampus Cortex Neuroproteomics Closed head injury 
GenomicsClosed Head Injury Inulin Mouse Stool Samples
Closed Head Injury Inulin Mouse Stool Samples Raw sequence reads
PRJNA903182 | ENA
GenomicsBulk RNA-seq of mouse brain following closed head injury: role of IL-1R1 signaling
Bulk RNA-seq of mouse brain following closed head injury: role of IL-1R1 signaling
PRJNA1445297 | ENA
UnknownRepeated Closed Head Injury in Mice Results in Sustained Motor and Memory Deficits and Chronic Cellular Changes.
Not available
S-EPMC4948770 | biostudies-literature
GenomicsRepetitive mild closed head injury in adolescent mice is associated with impaired proteostasis, neuroinflammation, and tauopathy
Repetitive mild closed head injury in adolescent mice is associated with impaired proteostasis, neuroinflammation, and tauopathy
PRJNA705646 | ENA
TranscriptomicsBulk RNA-seq of mouse brain following closed head injury: role of IL-1R1 signaling
Bulk RNA-seq was performed on brain tissue from mice following closed head injury (CHI) or sham surgery at 9h, 24h, and 72h post-injury. Four genotypes were studied: C57BL/6J wild-type, IL-1R1 global knockout (gKO), IL-1R1 endothelial restore (eRestore), and IL-1R1 neuronal restore (nRestore) to dis...
ORGANISM(S): Mus musculus 
2026-07-29 | GSE326452 | GEO
TranscriptomicsChanges in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury
Warfare has long been associated with traumatic brain injury (TBI) in militarized zones. Common forms of TBI can be caused by a physical insult to the head-brain or by the effects of a high velocity blast shock wave generated by the detonation of an explosive device. While both forms of trauma are d...
ORGANISM(S): Mus musculus 
2013-03-18 | E-GEOD-44625 | biostudies-arrayexpress
UnknownIL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury.
Not available
S-EPMC10601112 | biostudies-literature
UnknownmodCHIMERA: a novel murine closed-head model of moderate traumatic brain injury.
Not available
S-EPMC5955903 | biostudies-literature
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