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MetabolomicsBlocking Toxin function and Modulating Gut Microbiota: Caffeic Acid and its Derivatives as Potential Treatments for Clostridioides difficile Infections

Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea that seriously threaten public health. Disruption of normal gut microbiota by the use of broad-spectrum antimicrobial agents enables C. difficile to proliferate in the colon. The emergence and prevalence o...

2024-06-04 | MTBLS9938 | MetaboLights
TranscriptomicsModulation of mucosal immune responses to Clostridium difficile by peroxisome proliferator-activated receptor γ and microRNA-146b
BACKGROUND: miRNA have been shown to play an important role during immune-mediated diseases such as inflammatory bowel disease. The aim of this study was to assess differential expression of miRNA between uninfected and infected mice with Clostridium difficile strain VPI 10463 RESULTS: MicroRNA (miR...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-39235 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of Clostridium difficile strains to identify markers of different ribotypes
Clostridium  difficile  (C. difficile) strains belonging to PCR ribotype 027, PFGE type NAP1, REA type B1 and toxinotype III, termed NAP1/027, have been implicated in the increased frequency of outbreaks of Clostridium difficile-associated diarrhoea (CDAD) in North America and Europe. The NAP1/027 s...
ORGANISM(S): Clostridium difficile 
2010-07-01 | E-MTAB-162 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of temporal gene expression in germinating Clostridium difficile 630 endospores
Clostridium difficile is the leading cause of hospital acquired diarrhoea in industrialised countries. Under conditions that are not favourable for growth, the pathogen produces metabolically dormant endospores via asymmetric cell division. These are extremely resistant to both chemical and physical...
ORGANISM(S): Clostridium difficile 
2013-03-16 | E-BUGS-145 | biostudies-arrayexpress
MetabolomicsGlutathione is a host-derived cysteine source for Clostridioides difficile
Clostridioides difficile is the leading cause of nosocomial diarrhea, afflicting approximately half a million people each year in the USA, burdening both individuals’ quality of life and the healthcare system. In the gastrointestinal (GI) tract, C. difficile must acquire essential nutrients to colon...
2026-06-10 | MTBLS14740 | MetaboLights
TranscriptomicsTranscription profiling of Caco-2 cells and Clostridium difficile during infection
Clostridium difficile is an anaerobic spore-forming rod-shaped gram-positive bacterium that can infect both humans and animals. Most studies on the pathogenesis of C. difficile have focused on its toxins and their effect on the host cells. Recently, we utilized microarrays to identify conserved and ...
ORGANISM(S): Homo sapiens 
2010-08-07 | E-GEOD-18407 | biostudies-arrayexpress
TranscriptomicsHuman colon epithelial treated with Clostridium difficile Toxins A and B
Toxin A and B from Clostridium difficile are the primary virulence factors in Clostridium difficile disease. The changes in gene transcription of human colon epithelial cells were investigated in vitro in order to better understand the many effects of both toxins. HCT-8 cells were treated with 100 n...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29008 | biostudies-arrayexpress
TranscriptomicsEffect of sigH in the growth phase transition of Clostridium difficile
This SuperSeries is composed of the following subset Series: GSE25474: Comparison of the expression profiles of 630E strain after 4h and 10h of growth GSE25475: Comparison of the expression profiles of 630E strain and a sigH mutant after 10h of growth This study is based on two microarray datasets,...
ORGANISM(S): [Clostridium] difficile 
2011-08-21 | E-GEOD-25521 | biostudies-arrayexpress
MetabolomicsEctopic intestinal colonization by an oral commensal promotes C. difficile infection in Crohn’s disease
Crohn’s disease is a severe inflammatory disorder of the intestine for which there is no cure. People suffering from Crohn’s disease are at increased risk of developing Clostridioides difficile infection (CDI), which considerably exacerbates symptoms. Using a prospective observational clinical study...
2025-08-14 | MTBLS12275 | MetaboLights
TranscriptomicsBacteroides (Phocaeicola)-driven metabolic remodelling suppresses Clostridioides difficile toxin expression in mixed biofilm communities
The aim of this study was to investigate transcriptomic changes in Clostridioides difficile when cultured as monoculture biofilms or as co-culture biofilms with either Bacteroides (Phocaeicola) dorei or Bacteroides (Phocaeicola) vulgatus. This study was also interested in transcriptomic changes occu...
ORGANISM(S): Phocaeicola vulgatus 
2026-09-23 | E-MTAB-15641 | biostudies-arrayexpress
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