Sort   by:  
 Page size 
ProteomicsDeciphering nuclear polyp function during human cell proliferation
Nuclear speckles (NS) are membrane-less nuclear organelles that act as critical hubs for pre-mRNA splicing. Defects in splicing are linked to several human diseases, including cancer, Alzheimer's disease, and dystrophies. While CLK kinases regulate the mobilization of splicing factors from NS, the m...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD065723 | Pride
Polyphosphate Ppbd Nuclear speckle Srrm2 Proximity labelling 
ProteomicsDeciphering nuclear polyp function during human cell proliferation (MCI) PID2021-127302NB-I00
Nuclear speckles (NS) are membrane-less nuclear organelles that act as critical hubs for pre-mRNA splicing. Defects in splicing are linked to several human diseases, including cancer, Alzheimer's disease, and dystrophies. While CLK kinases regulate the mobilization of splicing factors from NS, the m...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD059084 | Pride
Polyphosphate Ppbd Nuclear speckle Srrm2 Proximity labelling 
UnknownAtypical cyclins: the extended family portrait.
Not available
S-EPMC6971155 | biostudies-literature
UnknownAtypical cyclin P regulates cancer cell stemness through activation of the WNT pathway.
Not available
S-EPMC8648692 | biostudies-literature
ProteomicsPlitidepsin is a broad-spectrum antiviral that transiently inhibits viral 1 protein translation and shapes a protective proteostatic cellular response
Plitidepsin is a safe antiviral for COVID-19 patients that impairs SARS-CoV-2 replication by targeting host factors implicated in protein translation. Here we used deep quantitative proteomics coupled to infectious assays and transmission electron microscopy to dissect its antiviral activity. Plitid...
ORGANISM(S): Chlorocebus 
2024-12-19 | PXD041854 | Pride
Plitidepsin Tmt Orbitrap eclipse Sars-cov-2 Covid-19 
UnknownMethylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control.
Not available
S-EPMC7410168 | biostudies-literature
UnknownTargeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m<sup>6</sup>A protein synthesis routes.
Not available
S-EPMC11805953 | biostudies-literature
UnknownPreclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2.
Not available
S-EPMC9893798 | biostudies-literature
UnknownEpigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome.
Not available
S-EPMC8938861 | biostudies-literature
UnknownBiological therapies for inflammatory pouch disorders: insights and outcomes from the RESERVO study of GETECCU.
Not available
S-EPMC12925033 | biostudies-literature
Sort   by:  
 Page size