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GENEVA: The Genes and Blood Clotting Study
Mitochondrial gene expression is required for platelet function and blood clotting
Platelets are anucleate blood cells that contain mitochondria, that regulate blood clotting in response to injury. Mitochondria contain their own gene expression machinery which relies on nuclear encoded factors for the biogenesis of the oxidative phosphorylation (OXPHOS) system to produce energy, i...
ORGANISM(S): Mus musculus 
2023-10-03 | GSE206543 | GEO

Objectives: Use genome-wide approaches to identify genetic variants that influence common thrombosis and hemostasis factors, as well as selected common human traits.

Design/Methods: The GABC study was a prospective sibling cohort design. Siblings were recruited by targeted em...

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