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Maintenance of mitochondria is achieved by several mechanisms, including the regulation of mitochondrial proteostasis. The matrix protease CLPXP, involved in protein quality control, has been implicated in ageing and disease. However, particularly due to the lack of knowledge of CLPXP’s substrate sp...
ORGANISM(S): Podospora 
2016-07-27 | PXD003264 | Pride
A defining feature of bacteria is the peptidoglycan cell wall that confers cell shape and protects cells from osmotic lysis. While peptidoglycan hydrolases, or autolysins, are required for incorporation of new cell wall material and for separation of daughter cells, dysregulated autolytic activity m...
ORGANISM(S): Staphylococcus aureus 
2025-05-23 | PXD053967 | Pride
we treated the cell lysates of ΔclpX mutant with or without P. aeruginosa ClpXP protease and used Label-free quantitative techniques (LFQ) to identify and quantify the proteolytic targets of ClpXP (p.aeruginosa PAO1). As a result, 3338 proteins were identified and 2493 proteins were quantified. The ...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2020-04-29 | PXD014928 | Pride
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