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GenomicsAlzheimer’s Disease Protective Allele of CLU Promotes Neuron Excitability, Neuron-glia Lipid Transfer and Astrocytic Lipid Droplets via neuronal CLU
Alzheimer’s Disease Protective Allele of CLU Promotes Neuron Excitability, Neuron-glia Lipid Transfer and Astrocytic Lipid Droplets via neuronal CLU
PRJNA1120422 | ENA
GenomicsClu regulate myeloid bias in aged hematopoietic stem cells
Clu regulate myeloid bias in aged hematopoietic stem cells
PRJNA1150988 | ENA
UnknownDrosophila Clu ribonucleoprotein particle dynamics rely on the availability of functional Clu and translating ribosomes.
Not available
S-EPMC12136168 | biostudies-literature
ProteomicsSORL1 regulates APOE and CLU levels in human neurons
SORL1 is implicated in the pathogenesis of Alzheimer’s disease (AD) through genetic studies. To interrogate the role(s) of SORL1 in human brain cells, SORL1 null iPSCs are differentiated to neuron, astrocyte, microglial, and endothelial cell fates. Loss of SORL1 leads to alterations in both overlapp...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD044093 | Pride
Lc-ms/ms Alzheimer's Tmt 
GenomicsInjury-Induced CLU-Positive Cardiomyocytes Drive Metabolic Reprogramming of Macrophage Function in Heart Regeneration [10X_chromium]
Injury-Induced CLU-Positive Cardiomyocytes Drive Metabolic Reprogramming of Macrophage Function in Heart Regeneration [10X_chromium]
PRJNA1067571 | ENA
TranscriptomicsAlzheimer’s Disease Protective Allele of CLU Promotes Neuron Excitability, Neuron-glia Lipid Transfer and Astrocytic Lipid Droplets via neuronal CLU
Disease causal mechanism remains largely unknown for most Alzheimer’s disease (AD) genome-wide association studies (GWAS) risk loci, including the Clusterin (CLU) locus. Here, leveraging our approach to identify functional GWAS risk variants that show allele-specific open chromatin (ASoC), we nomina...
ORGANISM(S): Mus musculus Homo sapiens 
2024-06-10 | GSE269153 | GEO
GenomicsInjury-Induced CLU-Positive Cardiomyocytes Drive Metabolic Reprogramming of Macrophage Function in Heart Regeneration [stero-seq]
Injury-Induced CLU-Positive Cardiomyocytes Drive Metabolic Reprogramming of Macrophage Function in Heart Regeneration [stero-seq]
PRJNA1068455 | ENA
ProteomicsIsotopic N,N-dimethyl leucine tags for absolute quantification of clusterin and apolipoprotein E in Alzheimer's disease
Alzheimer’s disease (AD) is the most common form of dementia and one of the leading causes of death in the United States. In past decades, extensive efforts have been devoted to improving our understanding of AD pathogenesis and accelerating biomarker discovery for early diagnosis and clinical treat...
ORGANISM(S): Homo sapiens (Human) 
2022-10-05 | PXD030724 | Pride
Protein quantitation Biomarker analysis Alzheimer’s disease Clusterin Isotopic labeling Serum Apolipoprotein e Absolute quantification 
GenomicsInjury-Induced CLU-Positive Cardiomyocytes Drive Metabolic Reprogramming of Macrophage Function in Heart Regeneration [Spatial Transcriptomics]
Injury-Induced CLU-Positive Cardiomyocytes Drive Metabolic Reprogramming of Macrophage Function in Heart Regeneration [Spatial Transcriptomics]
PRJNA1068456 | ENA
GenomicsCLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density [scRNA-seq]
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density [scRNA-seq]
PRJNA1223439 | ENA
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