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MetabolomicsA Pathogen-Responsive Gene Cluster for Highly Modified Fatty Acids in Tomato
In response to biotic stress, plants produce suites of highly modified fatty acids that bear unusual chemical functionalities. Despite their chemical complexity and proposed roles in pathogen defense, little is known about the biosynthesis of decorated fatty acids in plants. Falcarindiol is a protot...
2022-01-17 | MTBLS1039 | MetaboLights
MetabolomicsProduction of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027

Natural products from microorganisms are important sources for drug discovery. With the development of high-throughput sequencing technology and bioinformatics, a large amount of uncharacterized biosynthetic gene clusters (BGCs) in microorganisms have been found, which show the potential for nove...

2023-09-06 | MTBLS5152 | MetaboLights
MetabolomicsSingle-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC count may not be the 'best' indicator of metastatic risk because their heterogeneity is generally neglected. In this study, we develop a molecular typing system to predict colorectal cancer metastasis potent...

2023-08-21 | MTBLS5028 | MetaboLights
TranscriptomicsTranscription profiling of human cluster headache patients peripheral blood on Affymetrix arrays vs. controls
Background - Cluster headache (CH) is a primary neurovascular headache disorder characterized by attacks of excruciating pain accompanied by ipsilateral autonomic symptoms. CH pathophysiology is presumed to involve an activation of hypothalamic and trigeminovascular systems, but inflammation and imm...
ORGANISM(S): Homo sapiens 
2011-04-27 | E-MTAB-631 | biostudies-arrayexpress
GenomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
This SuperSeries is composed of the following subset Series: GSE32362: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (Illumina HumanMethylation450 BeadChip) GSE33129: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mamm...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-33130 | biostudies-arrayexpress
TranscriptomicsAnalysis of a fungus-specific transcription factor family, the Candida albicans zinc cluster proteins, by artificial activation
The zinc cluster proteins are a family of transcription factors that are unique to the fungal kingdom. In the pathogenic yeast Candida albicans, zinc cluster transcription factors control the expression of virulence-associated traits and play key roles in the development of antifungal drug resistanc...
ORGANISM(S): Candida albicans 
2013-07-29 | E-GEOD-48259 | biostudies-arrayexpress
GenomicsRNA sequencing in blood samples of cluster headache patients
Cluster headache is a relatively rare headache disorder, typically characterized by multiple daily, short-lasting attacks of excruciating, unilateral (peri-)orbital or temporal pain associated with autonomic symptoms and restlessness. To better understand the pathophysiology of cluster headache, we ...
EGAS00001001918 | EGA
TranscriptomicsCluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy
Overall, the widely disparate transcriptomes identified prior to RT among the three clusters support the notion that at least some of the inter-individual heterogeneity in propensity for RT-induced myofiber hypertrophy is likely pre-determined. Baseline comparisons of skeletal muscle transcript prof...
ORGANISM(S): Homo sapiens 
2013-05-24 | E-GEOD-42507 | biostudies-arrayexpress
TranscriptomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (Infinium HumanMethylation450 Beadchip)
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we used the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modif...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-32362 | biostudies-arrayexpress
TranscriptomicsMaize gene expression during infection with the Ustilago maydis mutant for cluster 19A and subdeletions for individual genes of cluster 19A
Many of the genes coding for secreted protein effectors are arranged in gene clusters in the genome of the biotrophic plant pathogen Ustilago maydis. The largest of these gene clusters, cluster 19A, encodes 24 secreted effectors. Deletion of the entire cluster results in severe attenuation of virule...
ORGANISM(S): Zea mays 
2014-09-01 | E-GEOD-48406 | biostudies-arrayexpress
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