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MetabolomicsBiosynthesis of Isonitrile Lipopeptides by Conserved Non-ribosomal Peptide Synthetase Gene Clusters in Actinobacteria
A putative lipopeptide biosynthetic gene cluster is conserved in many species of Actinobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum, but the specific function of the encoding proteins has been elusive. Using both in vivo heterologous reconstitution and in vitro biochemica...
2017-07-18 | MTBLS454 | MetaboLights
GenomicsThe Dynamic Architecture of Hox Gene Clusters
The spatial and temporal control of Hox gene transcription is essential for patterning the vertebrate body axis. Although this process involves changes in histone posttranslational modifications, the existence of particular three-dimensional (3D) architectures remained to be assessed in vivo. Using ...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-31570 | biostudies-arrayexpress
ProteomicsTranslation Error Clusters Induced by Aminoglycoside Antibiotics
Aminoglycoside antibiotics target the ribosome and induce mistranslation, yet which translation errors induce bacterial cell death is unclear. The analysis of cellular proteins by quantitative mass spectrometry shows that bactericidal aminoglycosides induce not only single errors, but also clusters ...
ORGANISM(S): Escherichia coli 
2021-04-06 | PXD022098 | Pride
Aminoglycosides 
GenomicsBreast Cancer - immune clusters - RNA-seq
In this study we use expression data from breast cancer tumors to define immune clusters in breast cancer. Immune clusters have gradual levels of immune infiltration. In the intermediate immune infiltration cluster, we found a worse prognosis which is independent of known clinicopathological feature...
EGAS00001003631 | EGA
TranscriptomicsMicroarray analyses of rachis tissue extracted from control and BS affected grape clusters
Transcriptional expression in the rachis of pre-sympotmatic (T1) and symptomatic (T2) berry shrivel (BS) clusters in comparison to control samples. Samples were collected from a vineyard in Mailberg, Lower Austria, in 2011 from cultivar Blauer Zweigelt (Vitis vinifera) grafted on Kober 5BB. The obje...
ORGANISM(S): Vitis vinifera 
2022-09-01 | E-MTAB-12113 | biostudies-arrayexpress
TranscriptomicsmicroRNA and mRNA expression profiles of human pancreatic islet-like cell clusters
Type 1 diabetes is an autoimmune destruction of pancreatic islet beta cell disease, and it is important to find new alternative source of the islet beta cells to replace the damaged cells. Human embryonic stem (hES) cells possess unlimited self-renewal and pluripotency and thus have the potential to...
ORGANISM(S): Homo sapiens 
2010-09-29 | E-GEOD-14503 | biostudies-arrayexpress
TranscriptomicsEpigenetic profiling at mouse imprinted gene clusters
Epigenetic profiling of DNA methylation, histone H3 lysine 4 trimethylation and histone H3 lysine 9 trimethylation at imprinted gene clusters in the mouse. Imprinted control regions were identified by comparing DNA and histone methylation patterns between sperm, heart and cerebellum.
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-16588 | biostudies-arrayexpress
ProteomicsTranslation Error Clusters Induced by Aminoglycoside Antibiotics
Aminoglycoside antibiotics (AGAs) target the ribosome and induce mistranslation, yet which translation errors induce bacterial cell death is unclear. The analysis of cellular proteins by quantitative mass spectrometry shows that bactericidal AGAs induce not only single translation errors, but also c...
ORGANISM(S): Escherichia Coli 
2021-04-06 | PXD019328 | panorama
GenomicsBreast Cancer - immune clusters - RNA-seq
Breast Cancer - immune clusters - RNA-seq
PRJNA558331 | ENA
TranscriptomicsExpression of microRNAs and their target mRNAs in hESC-derived cardiomyocyte clusters and in heart tissue_mRNA_data
Parallel transcription profiling of cardiomyocyte clusters derived from human embryonic stem cells. Both mRNA (this experiment) and miRNA (see E-MEXP-2655) transcription are measured and fetal and adult heart tissues are included as controls. This experiment was updated on 7th July 2011 to fix incor...
ORGANISM(S): Homo sapiens 
2011-03-30 | E-MEXP-2654 | biostudies-arrayexpress
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