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ProteomicsA structural model for the autoinhibition of the γ-TuRC-activating CM1 domain
Microtubule nucleation by γ-tubulin ring complexes (γ-TuRCs) must be spatiotemporally controlled to avoid major cell division errors. γ-TuRCs are activated by the centrosome-specific binding of a highly conserved Centrosomin Motif 1 (CM1) domain, but how binding is prevented in the cytosol remains u...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-10-01 | PXD077066 | Pride
Saxs Cm1 domain Autoinhibition Γ-turcs Hdx-ms Nmr 
ProteomicsReconstitution of microtubule nucleation in vitro reveals novel roles for Mzt1
Protein-protein interaction within the MGM holocomplex has been investigated by chemical cross-linking mass spectrometry using EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) cross-linker. Although this analysis was not exhaustive, we observed crosslinks between Alp4 and Alp6 along the length of...
ORGANISM(S): Schizosaccharomyces pombe 
2019-05-27 | PXD012624 | Pride
“mgm” (mto/gamma/mozart) holocomplex Cross-linking 
UnknownPathogenic gain-of-function mutations in the prodomain and C-terminal domain of PCSK9 inhibit LDL binding.
Not available
S-EPMC9515655 | biostudies-literature
UnknownAutoinhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defects.
Not available
S-EPMC8164090 | biostudies-literature
UnknownAudiovestibular Findings in a Cohort of Patients with Chiari Malformation Type I and Dizziness.
Not available
S-EPMC10142081 | biostudies-literature
TranscriptomicsSequencing of murine corticotrophs from male POMC-GFP mice subjected to chronic restraint stress
Stress-related illness represents a major burden on health and society. Understanding the molecular mechanisms underlying stress responses is an important step to understanding these diseases and designing treatments. Corticotrophs of the anterior pituitary play a central role in the generation of h...
ORGANISM(S): Mus musculus 
2024-10-30 | E-MTAB-13648 | biostudies-arrayexpress
UnknownMOZART1 and γ-tubulin complex receptors are both required to turn γ-TuSC into an active microtubule nucleation template.
Not available
S-EPMC5166503 | biostudies-literature
UnknownReconstitution of Microtubule Nucleation In Vitro Reveals Novel Roles for Mzt1.
Not available
S-EPMC6616311 | biostudies-literature
UnknownMultifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes.
Not available
S-EPMC10497398 | biostudies-literature
TranscriptomicsGenomic alterations during the progress of pulmonary hypertension
Pulmonary hypertension (PH), a rare disorder is a complication of a number of cardiopulmonary, unrelated systemic diseases, drug toxicity and genetic mutations. Major advances have been made in the field, but the pathogenesis of PH is not yet understood. Several experimental models such as monocro...
ORGANISM(S): Rattus norvegicus 
2015-09-04 | E-GEOD-72707 | biostudies-arrayexpress
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