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TranscriptomicsA chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates.
Injury to the central nervous system (CNS) may result in lifelong loss of function due, in part, to the regenerative failure of CNS neurons. Major barriers to regeneration faced by injured CNS neurons include inhibitory proteins derived from myelin and the astroglial scar. Previously, we described...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-34331 | biostudies-arrayexpress
MetabolomicsPolystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism

Microplastics and nanoplastics are commonly found in our everyday environments. So far, microplastics and nanoplastics have been detected in various tissues and bodily fluids, including hair, sputum, digestive tissue, lungs, blood, and placental tissue. Although some studies indicate that micropl...

2026-02-05 | MTBLS13850 | MetaboLights
TranscriptomicsTranscriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiation
One of the key aspects of neuronal differentiation is the array of neurotransmitters and neurotransmitter receptors that each neuron possesses. One important goal of developmental neuroscience is to understand how these differentiated properties are established during development. In this paper, we ...
ORGANISM(S): Drosophila melanogaster 
2012-10-12 | E-GEOD-41510 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional profiling of Th17 cells, harvested at peak of disease in EAE from CNS [EAE-CNS-IL-17A/GFP+]
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75107 | biostudies-arrayexpress
TranscriptomicsDysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been proposed to result from the combined effects of damage to oligodendrocytes and failure of remyelination. A common feature of demyelinated lesions is the presence of oligodendrocyte precursors (OLPs) blocked at a pre...
ORGANISM(S): Mus musculus 
2009-12-10 | E-GEOD-19403 | biostudies-arrayexpress
TranscriptomicsKinesin-associated RNA: RNA co-immunoprecipitated with Kinesin IP vs RNA from Aplysia CNS
Whole genome transcriptional profiling is used to identify ESTs found in RNA co-immunoprecipitated from Aplysia CNS with antibodies against Aplysia Kinesin Heavy Chain (ApKHC) RNA derived from Aplysia CNS served as control in the opposite channel. Custom Aplysia EST array to probe the samples was de...
ORGANISM(S): Aplysia californica 
2013-04-26 | E-GEOD-30386 | biostudies-arrayexpress
TranscriptomicsIdentification of Myelin-gene Regulatory Factor as a Critical Transcriptional Regulator Required for CNS Myelination
The transcriptional control of CNS myelin gene expression is poorly understood. Here we identify gene model 98, which we have named Myelin-gene Regulatory Factor (MRF), as a transcriptional regulator required for CNS myelination. Within the CNS, MRF is specifically expressed by postmitotic oligodend...
ORGANISM(S): Mus musculus 
2009-05-31 | E-GEOD-15303 | biostudies-arrayexpress
TranscriptomicsPopulation transcriptional profiling of Th17 cells, isolated from CNS or LN at peak of disease in EAE
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75105 | biostudies-arrayexpress
TranscriptomicsDrosophila CNS glial microarray
Gliogenesis in the Drosophila CNS occurs during embryogenesis and also during the postembryonic larval stages. Several glial subtypes are generated in the postembryonic CNS through the proliferation of differentiated glial cells. The genes and molecular pathways that regulate glial proliferation in ...
ORGANISM(S): Drosophila melanogaster 
2013-04-24 | E-GEOD-46317 | biostudies-arrayexpress
GenomicsNew Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein we demonstrate that a significant proportion of institutionally diagnos...
EGAS00001001632 | EGA
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