Sort   by:  
 Page size 
GenomicsGene-specific transcript buffering revealed by perturbation of coactivator complexes
Gene-specific transcript buffering revealed by perturbation of coactivator complexes
PRJNA1232156 | ENA
TranscriptomicsANGUSTIFOLIA 3 binds SWI/SNF chromatin remodeling complexes to regulate transcription during Arabidopsis leaf development
The transcriptional coactivator ANGUSTIFOLIA 3 (AN3) stimulates cell proliferation during Arabidopsis leaf development, but the molecular mechanism is largely unknown. We show here that inducible nuclear localization of AN3 during initial leaf growth results in differential expression of important t...
ORGANISM(S): Arabidopsis thaliana 
2014-09-09 | E-GEOD-42875 | biostudies-arrayexpress
GenomicsSAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers
Metazoan SAGA and ATAC are distinct multi-subunits complexes that share the same catalytic HAT subunit (GCN5 or PCAF). Here we show that these human HAT complexes are targeted to different genomic loci representing functionally distinct regulatory elements both at broadly expressed and tissue specif...
ORGANISM(S): Homo sapiens 
2011-11-05 | E-GEOD-31052 | biostudies-arrayexpress
ProteomicsTwo related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through two different acetyltransferase-independent mechanisms
SAGA and ATAC are two related transcriptional coactivator complexes, sharing the same histone acetyltransferase (HAT) subunit. The HAT activities of SAGA and ATAC are required for metazoan development but the precise role of the two complexes in RNA polymerase II transcription in mammals is less und...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-11 | PXD027026 | Pride
Saga Newly synthesized rna Histone acetyltransferase 4su labelling Atac Pol ii transcription Hat-independent function Mouse embryonic stem cells Coactivator complexes 
GenomicsATAC and Mediator coactivators form a stable complex and regulates a set of non-coding RNA genes
The ATAC histone acetyl-transferase (HAT) and the Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here we report the identification of a new stable molecular assembly formed between the ATAC and the Mediator complex in mouse embr...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-21717 | biostudies-arrayexpress
UnknownA scoring system for the follow up study of nuclear receptor coactivator complexes.
Not available
S-EPMC1513068 | biostudies-literature
TranscriptomicsAblation of coactivator Med1 regulates bulge keratinocyte stem cells and accelerates epidermal regeneration after injury [10wk skin]
Transcriptional coactivator Mediator complex facilitates transcription of various transcription factors. Previously, we have generated Med1 conditional null mice, where a critical subunit of Mediator, Med1, is removed from keratinocytes. Here we present evidence that ablation of Med1 accelerated epi...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-50671 | biostudies-arrayexpress
UnknownDissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand.
Not available
S-EPMC4143068 | biostudies-literature
UnknownDomains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.
Not available
S-EPMC3028633 | biostudies-literature
TranscriptomicsAblation of coactivator Med1 regulates bulge keratinocyte stem cells and accelerates epidermal regeneration after injury [10wk keratinocyte]
Transcriptional coactivator Mediator complex facilitates transcription of various transcription factors. Previously, we have generated Med1 conditional null mice, where a critical subunit of Mediator, Med1, is removed from keratinocytes. Here we present evidence that ablation of Med1 accelerated epi...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-50672 | biostudies-arrayexpress
Sort   by:  
 Page size