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TranscriptomicsExpression data from the seed coats of black (iRT) and brown (irT) soybean variant for alleles of the R locus
The seed coat of black (iRT) soybean with the dominant R allele begins to accumulate cyanic pigments at the transition stage of seed development (300 – 400 mg fresh seed weight), whereas the brown (irT) nearly-isogenic seed coat with the recessive r allele lacks cyanic pigments at all stages of seed...
ORGANISM(S): Glycine max 
2011-08-22 | E-GEOD-26208 | biostudies-arrayexpress
GenomicsMethylation Changes in Soybean Early Maturation Seed Parts
What methylation changes are occurring in different parts of early maturation stage seed largely remains unknown. To uncover the possible role of DNA methylation in different parts of early maturation stage seed, we characterized the methylome of seed coats,cotyledons, and the embryonic seed axis us...
ORGANISM(S): Glycine max 
2012-05-11 | E-GEOD-37895 | biostudies-arrayexpress
TranscriptomicsIdentification of soybean seed developmental stage specific and tissue specific miRNA targets by degradome sequencing .
Five degradome libraries were constructed from three different seed developmental stages. Separate degradome libraries were constructed for seed coat and cotyledons to identify the tissue specific miRNAs and their potential targets. Sequencing and analysis of degradome libraries gives identification...
ORGANISM(S): Glycine max 
2012-08-07 | E-GEOD-34433 | biostudies-arrayexpress
TranscriptomicsThe Epstein-Barr virus induced tumor suppressor miR-34a is growth promoting in EBV-infected B cells
Epstein-Barr virus (EBV) infection of primary human B cells drives their indefinite proliferation into lymphoblastoid cell lines (LCLs). B cell immortalization depends on expression of viral latency genes as well as the regulation of host genes. Given the important role of miRNAs in regulating fund...
ORGANISM(S): Homo sapiens 
2012-04-19 | E-GEOD-36926 | biostudies-arrayexpress
TranscriptomicsGene expression of mantle cell lymphoma-initiating cells from primary tumor samples
In this study we compared the expression of 30215 genes in mantle cell lymphoma-initiating cells (MCL-ICs) with mantle cell lymphoma-non-initiating cells (MCL-non-ICs) and B-cells from healthy donor Three samples each of MCL-ICs and MCL-non-ICs were isolated from aphresis of 3 mantle cell lymphoma p...
ORGANISM(S): Homo sapiens 
2014-08-02 | E-GEOD-60023 | biostudies-arrayexpress
TranscriptomicsCD40-activation of human B cells
Antibody-independent effector functions of B cells, such as antigen presentation and cytokine production, have been shown to play an important role in a variety of immune-mediated conditions such as autoimmune diseases, transplant rejection and graft-versus-host disease. Therapeutic strategies, whi...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-54017 | biostudies-arrayexpress
TranscriptomicsSimilarities and differences between macrophage polarized gene profiles (Illumina)
The human AA dataset 5 includes the gene expression profile of monocyte-derived macrophages isolated from blood donor buffy coats and plated on TCP in medium containing 10% autologous serum. Cells were stimulated for 120 hours with 50 ng/ml of IL-4, 50 U/ml of IFN-γ plus 12.5 ng/ml of TNF-α, 50 ng/m...
ORGANISM(S): Homo sapiens 
2013-07-26 | E-GEOD-49240 | biostudies-arrayexpress
TranscriptomicsComparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture
Bulk RNA-seq analysis of CLL cells cocultured for 5 days with (A) HD-MDMs, (B) NLCs, and (C)THP-1 macrophages compared to CLL cells in monoculture.
ORGANISM(S): Homo sapiens 
2025-09-01 | E-MTAB-15353 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of immature and LPS-matured dendritic cells, sorted for DC-S and DC-L phenotypes
We have described two human, monocyte-derived dendritic cells (DC), which we have termed DC-S (small) and DC-L (large). Human dendritic cells are significantly less well known that murine ones, yet they are a crucial player in the immune system, especially when considering options for immunotherapie...
ORGANISM(S): Homo sapiens 
2016-10-17 | E-MTAB-5075 | biostudies-arrayexpress
TranscriptomicsMetabolic stress is a barrier to Epstein-Barr virus mediated B-cell immortalization
Early after infection, Epstein-Barr Virus (EBV) induces a transient period of hyper-proliferation that is suppressed by the activation of the DNA damage response and a G1/S phase growth arrest. This growth arrest prevents long-term outgrowth of the majority of infected cells. We developed a method t...
ORGANISM(S): Homo sapiens 
2015-12-19 | E-GEOD-76137 | biostudies-arrayexpress
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