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ProteomicsNanoTACs: NanoLuc-Targeting Protein Degraders that Parallel Existing Technology
NanoLuc-targeting PROTACs (NanoTACs) hijack the CRBN and VHL cullin-RING ligase complexes to trigger proteasomal degradation of substrates tagged with the 19 kDa luminescent NanoLuc tag. In order to validate the system and confirm selective degradation of the target protein and assess any potential ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031371 | Pride
Lc-ms Human Protac 
ProteomicsPINK1-TOM-TIM23 complex SDA XL-MS
3xFLAG-tagged human wild-type PINK1 was expressed and immunoprecipitated with anti-FLAG beads. Chemical cross-linking MS (XL-MS) analysis using SDA and UV exposure was performed followed by in solution trypsin digestion and MS analysis.
ORGANISM(S): Homo Sapiens (human) 
2025-05-29 | PXD058526 | JPOST Repository
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