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GenomicsCodon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
PRJNA1234593 | ENA
GenomicsCodon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
PRJNA1234592 | ENA
OtherCodon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
Background Cells regulate protein synthesis in response to fluctuating nutrient availability through mechanisms that affect both translation initiation and elongation. Branched-chain amino acids, leucine, isoleucine, and valine, are essential nutrients. However, how their depletion affects translati...
ORGANISM(S): Mus musculus 
2025-09-02 | GSE291653 | GEO
TranscriptomicsCodon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
Background: Cells regulate protein synthesis in response to fluctuating nutrient availability through mechanisms that affect both translation initiation and elongation. Branched-chain amino acids, leucine, isoleucine, and valine, are essential nutrients. However, how their depletion affects translat...
ORGANISM(S): Mus musculus 
2025-09-02 | GSE291652 | GEO
UnknownCodon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation.
Not available
S-EPMC12476630 | biostudies-literature
ProteomicsCodon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
This study investigates the immediate effects of single, double, and triple branched-chain amino acid (BCAA) deprivation on translational dynamics in NIH3T3 cells. Using a multi-omics approach combining RNA-seq, ribosome profiling (Ribo-seq), quantitative proteomics, and tRNA charging assays, we sys...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-13 | PXD067949 | Pride
Proteomics Elongation bottleneck Nutrient stress response Mass spectrometry Nih3t3 cells Ribosome profiling Amino acid starvation Translation regulation Trna charging Codon-specific stalling 
ProteomicsChemotherapy-induced codon-specific immunopeptidome diversification
Deregulated mRNA translation in cancer is a source of aberrant protein production when tryptophan shortage is induced by anti-tumor immunity (refs). Tryptophan is decoded by only one codon, and currently the consequences of aberrant protein production in conditions of a shortage of amino acids decod...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044085 | Pride
Aberrant protein Mrna translation Tryptophan Leucine Ribosomal stalling Immunopeptidomics Neoepitopes 
GenomicsCodon Pair-Specific Translation Defects Induce Ribosome-Associated Quality Control to Avoid Proteotoxic Stress [mono_di_profiling]
Codon Pair-Specific Translation Defects Induce Ribosome-Associated Quality Control to Avoid Proteotoxic Stress [mono_di_profiling]
PRJNA1029560 | ENA
ProteomicsCELL LYSATE DATA only from “Selective stalling of human translation through small molecule engagement of the ribosome nascent chain”
Human genetics as well as pharmacological intervention reveal that Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) plays a key role in regulating the levels of plasma low density lipoprotein cholesterol (LDL-C). Here we demonstrate that the compound PF-06446846 inhibits translation of PCSK9 by...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD005835 | Pride
Translational stalling Silac Pcsk9 Huh7 cells 
GenomicsCodon Pair-Specific Translation Defects Induce Ribosome-Associated Quality Control to Avoid Proteotoxic Stress [5P-seq]
Codon Pair-Specific Translation Defects Induce Ribosome-Associated Quality Control to Avoid Proteotoxic Stress [5P-seq]
PRJNA1029561 | ENA
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